Cenpb centromere protein B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cenpbprovided by MGI
Official Full Name: centromere protein Bprovided by MGI
Primary source: MGI:MGI:88376
See related: Ensembl:ENSMUSG00000068267 AllianceGenome:MGI:88376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CENP-B
Summary: Predicted to enable DNA binding activity. Located in condensed chromosome, centromeric region and pericentric heterochromatin. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.29 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (131019209..131021987, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (131177289..131180067, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parallel pathways for recruiting effector proteins determine centromere drive and suppression.
Title: Parallel pathways for recruiting effector proteins determine centromere drive and suppression.
CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
Title: CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
demonstrate a novel ADA3 interaction with CENP-B-centromere that may account for its previously known function in mitosis
Title: Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle Regulator, Associates with the Centromere through CENP-B and Regulates Chromosome Segregation.
Propose that CENP-B plays a dual role in centromere formation, ensuring de novo formation on DNA lacking a functional centromere but preventing the formation of excess centromeres on chromosomes.
Title: CENP-B controls centromere formation depending on the chromatin context.
Cenpa, Cenpb, and Bub3, but not Cenpc, interacted with PARP-1
Title: Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.
This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells.
Title: Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from Annotation Pipeline: 200 organisms have orthologs with human gene Cenpb
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables satellite DNA binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: major centromere autoantigen B

Names: centromere autoantigen B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007682.4 → NP_031708.2 major centromere autoantigen B

See identical proteins and their annotated locations for NP_031708.2

Status: VALIDATED

Source sequence(s)

AL831736

Consensus CDS

CCDS16757.1

UniProtKB/Swiss-Prot

P27790, Q7TSG8

Related

ENSMUSP00000086938.4, ENSMUST00000089510.5

Conserved Domains (4) summary

smart00674
Location:74 → 135

CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases

pfam03184
Location:222 → 384

DDE_1; DDE superfamily endonuclease

pfam04218
Location:2 → 56

CENP-B_N; CENP-B N-terminal DNA-binding domain

pfam09026
Location:539 → 598

CENP-B_dimeris; Centromere protein B dimerization domain