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ZNF440 zinc finger protein 440 [ Homo sapiens (human) ]

Gene ID: 126070, updated on 5-Aug-2022

Summary

Official Symbol
ZNF440provided by HGNC
Official Full Name
zinc finger protein 440provided by HGNC
Primary source
HGNC:HGNC:20874
See related
Ensembl:ENSG00000171295 AllianceGenome:HGNC:20874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in urinary bladder (RPKM 4.7), colon (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF440 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11814273..11835216)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11942472..11963418)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11925088..11946031)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 441 Neighboring gene uncharacterized LOC124904639 Neighboring gene zinc finger protein 491 Neighboring gene vomeronasal 2 receptor 13 pseudogene Neighboring gene zinc finger protein 439

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37933

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152357.3NP_689570.2  zinc finger protein 440

    See identical proteins and their annotated locations for NP_689570.2

    Status: VALIDATED

    Source sequence(s)
    AC008543
    Consensus CDS
    CCDS42503.1
    UniProtKB/Swiss-Prot
    Q8IYI8, Q8N1R9
    Related
    ENSP00000305373.5, ENST00000304060.10
    Conserved Domains (5) summary
    smart00349
    Location:444
    KRAB; krueppel associated box
    COG5048
    Location:199489
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:370390
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:382407
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11814273..11835216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438145.1XP_047294101.1  zinc finger protein 440 isoform X2

  2. XM_005259731.5XP_005259788.1  zinc finger protein 440 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:747
    KRAB; krueppel associated box
    COG5048
    Location:202492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:385410
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026254.2XP_016881743.1  zinc finger protein 440 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11942472..11963418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)