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OSCAR osteoclast associated, immunoglobulin-like receptor [ Homo sapiens (human) ]

Gene ID: 126014, updated on 19-Aug-2018

Summary

Official Symbol
OSCARprovided by HGNC
Official Full Name
osteoclast associated, immunoglobulin-like receptorprovided by HGNC
Primary source
HGNC:HGNC:29960
See related
Ensembl:ENSG00000170909 MIM:606862; Vega:OTTHUMG00000064966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIGR3; PIgR-3
Summary
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Expression
Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues See more
Orthologs

Genomic context

See OSCAR in Genome Data Viewer
Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (54094668..54102686, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54597933..54604159, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene TCF3 fusion partner Neighboring gene pre-mRNA processing factor 31 Neighboring gene uncharacterized LOC102724273 Neighboring gene CCR4-NOT transcription complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
collagen receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
collagen-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
osteoclast-associated immunoglobulin-like receptor
Names
osteoclast associated receptor OSCAR-S1
osteoclast associated receptor OSCAR-S2
poly-Ig receptor 3
polymeric immunoglobulin receptor 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282349.1NP_001269278.1  osteoclast-associated immunoglobulin-like receptor isoform 6 precursor

    See identical proteins and their annotated locations for NP_001269278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC245052, AF251702, AF391162, AF474153, BC035023
    Consensus CDS
    CCDS74444.1
    UniProtKB/Swiss-Prot
    Q8IYS5
    Related
    ENSP00000365808.2, OTTHUMP00000067447, ENST00000284648.10, OTTHUMT00000139493
    Conserved Domains (2) summary
    smart00410
    Location:38100
    IG_like; Immunoglobulin like
    cl11960
    Location:31124
    Ig; Immunoglobulin domain
  2. NM_001282350.1NP_001269279.1  osteoclast-associated immunoglobulin-like receptor isoform 7 precursor

    See identical proteins and their annotated locations for NP_001269279.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
    Source sequence(s)
    AC245052, AF251702, AF391162, AF474153, BC035023
    Consensus CDS
    CCDS62789.1
    UniProtKB/Swiss-Prot
    Q8IYS5
    Related
    ENSP00000479628.1, ENST00000616215.4
    Conserved Domains (2) summary
    smart00410
    Location:2789
    IG_like; Immunoglobulin like
    cl11960
    Location:20113
    Ig; Immunoglobulin domain
  3. NM_130771.4NP_570127.3  osteoclast-associated immunoglobulin-like receptor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC245052, AF251702, AF391162, AF391163, BC035023
    Consensus CDS
    CCDS12873.1
    UniProtKB/Swiss-Prot
    Q8IYS5
    UniProtKB/TrEMBL
    A0A087X1R2
    Related
    ENSP00000484401.1, ENST00000617140.4
    Conserved Domains (2) summary
    smart00410
    Location:42104
    IG_like; Immunoglobulin like
    cl11960
    Location:35128
    Ig; Immunoglobulin domain
  4. NM_133168.4NP_573398.2  osteoclast-associated immunoglobulin-like receptor isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC245052, AF251702, AF391162, AF391164, BC035023
    Consensus CDS
    CCDS12874.1
    UniProtKB/Swiss-Prot
    Q8IYS5
    UniProtKB/TrEMBL
    A0A0A0MR14
    Related
    ENSP00000304523.5, OTTHUMP00000067452, ENST00000351806.8, OTTHUMT00000139498
    Conserved Domains (2) summary
    smart00410
    Location:2789
    IG_like; Immunoglobulin like
    cl11960
    Location:20113
    Ig; Immunoglobulin domain
  5. NM_133169.4NP_573399.2  osteoclast-associated immunoglobulin-like receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_573399.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC245052, AF251702, AF391162, BC035023
    Consensus CDS
    CCDS12875.1
    UniProtKB/Swiss-Prot
    Q8IYS5
    UniProtKB/TrEMBL
    A0A0A0MRF2
    Related
    ENSP00000351145.4, OTTHUMP00000067450, ENST00000358375.8, OTTHUMT00000139496
    Conserved Domains (2) summary
    smart00410
    Location:38100
    IG_like; Immunoglobulin like
    cl11960
    Location:31124
    Ig; Immunoglobulin domain
  6. NM_206818.2NP_996554.2  osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC245052, AF251702, AF391162, AF474153, AK130199, BC035023
    Consensus CDS
    CCDS12876.1
    UniProtKB/Swiss-Prot
    Q8IYS5
    UniProtKB/TrEMBL
    A0A087WV17
    Related
    ENSP00000479089.1, ENST00000611261.4
    Conserved Domains (2) summary
    smart00410
    Location:42104
    IG_like; Immunoglobulin like
    cl11960
    Location:35128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    54094668..54102686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p12 ALT_REF_LOCI_8

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p12 ALT_REF_LOCI_9

    Range
    69046..77107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206817.1: Suppressed sequence

    Description
    NM_206817.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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