Format

Send to:

Choose Destination

COX6B2 cytochrome c oxidase subunit 6B2 [ Homo sapiens (human) ]

Gene ID: 125965, updated on 7-Jun-2020

Summary

Official Symbol
COX6B2provided by HGNC
Official Full Name
cytochrome c oxidase subunit 6B2provided by HGNC
Primary source
HGNC:HGNC:24380
See related
Ensembl:ENSG00000160471 MIM:618127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT59; COXVIB2
Expression
Restricted expression toward testis (RPKM 26.9) See more
Orthologs

Genomic context

See COX6B2 in Genome Data Viewer
Location:
19q13.42
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55349704..55354719, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55861070..55866182, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B Neighboring gene lysine methyltransferase 5C Neighboring gene family with sequence similarity 71 member E2 Neighboring gene interleukin 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cytochrome c oxidase subunit VIb polypeptide 2 (COX6B2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46422, MGC119094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial crista IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial crista IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 6B2
Names
COX VIb-2
cancer/testis antigen 59
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
cytochrome c oxidase subunit VIb, testes-specific

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369798.1NP_001356727.1  cytochrome c oxidase subunit 6B2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC020922, AK057427
    Related
    ENSP00000467266.1, ENST00000593184.5
    Conserved Domains (1) summary
    cd00926
    Location:1087
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
  2. NM_001369799.1NP_001356728.1  cytochrome c oxidase subunit 6B2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC020922
    Conserved Domains (1) summary
    cd00926
    Location:1087
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
  3. NM_001369800.1NP_001356729.1  cytochrome c oxidase subunit 6B2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC020922
    Conserved Domains (1) summary
    cd00926
    Location:1087
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
  4. NM_144613.5NP_653214.2  cytochrome c oxidase subunit 6B2

    See identical proteins and their annotated locations for NP_653214.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    BC026123, BG717038
    Consensus CDS
    CCDS42630.1
    UniProtKB/Swiss-Prot
    Q6YFQ2
    Related
    ENSP00000320672.3, ENST00000326529.9
    Conserved Domains (1) summary
    cd00926
    Location:1087
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55349704..55354719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center