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5 baseplate hub subunit and tail lysozyme [ Escherichia phage T4 ]

Gene ID: 1258817, updated on 31-May-2023
Gene symbol
5
Gene description
baseplate hub subunit and tail lysozyme
Locus tag
T4p144
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia phage T4 (nat-host: Escherichia coli)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Straboviridae; Tevenvirinae; Tequatrovirus
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Sequence:
NC_000866.4 (77959..79686)

NC_000866.4Genomic Context describing neighboring genes Neighboring gene tail protein Neighboring gene DNA end protector Neighboring gene head closure Neighboring gene baseplate wedge subunit Neighboring gene replication initiation protein Neighboring gene replication initiation protein Neighboring gene hypothetical protein Neighboring gene homing endonuclease Neighboring gene gp5.3 conserved hypothetical protein Neighboring gene PAAR motif of membran proteins

Genomic Sequence:
NC_000866.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Enhanced Sampling of Protein Conformational Transitions via Dynamically Optimized Collective Variables. Brotzakis ZF, et al. J Chem Theory Comput, 2019 Feb 12. PMID 30557019
  2. Density functional theory calculations on entire proteins for free energies of binding: application to a model polar binding site. Fox SJ, et al. Proteins, 2014 Dec. PMID 25212393
  3. The folding cooperativity of a protein is controlled by its chain topology. Shank EA, et al. Nature, 2010 Jun 3. PMID 20495548, Free PMC Article
  4. Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding. Liu L, et al. J Mol Biol, 2009 Jan 16. PMID 19014950
  5. Association and dissociation of the cell puncturing complex of bacteriophage T4 is controlled by both pH and temperature. Kumar Sarkar S, et al. Biochim Biophys Acta, 2006 Sep. PMID 16956798

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study implemented a recently developed variational approach to conformational dynamics metadynamics to the conformational transition of the moderate size protein, L99A mutant T4 Lysozyme. A Metadynamics simulation based on these information reveals the presence of two intermediate states, at an affordable computational cost.
    Title: Enhanced Sampling of Protein Conformational Transitions via Dynamically Optimized Collective Variables.
  2. Data suggest that the buried binding pocket of lysozyme can be manipulated (here using double mutant L99A/M102Q) to change observed affinity and thus free energy of binding as ligands bind this site.
    Title: Density functional theory calculations on entire proteins for free energies of binding: application to a model polar binding site.
  3. investigation of how the topological organization of T4 lysozyme protein (the order of structural elements along the sequence) affects the coupling and folding cooperativity between its domains
    Title: The folding cooperativity of a protein is controlled by its chain topology.
  4. The paper shows that the protein is flexible and adapts to the size and shape of the halogenated benzene ligands.
    Title: Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding.
  5. the lysozyme is inhibited before gp5 is cleaved and, presumably, the lysozyme is activated only after gp5 has penetrated the outer membrane in the infection of E coli
    Title: Control of bacteriophage T4 tail lysozyme activity during the infection process.
  6. When heated, the resulting (gp5*)3 dissociates into three gp5* and a c-terminal trimeric beta-helical structure. The interaction between gp27 and gp5* during infection is sundered by reducing pH.
    Title: Association and dissociation of the cell puncturing complex of bacteriophage T4 is controlled by both pH and temperature.
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Homology

rep_origin

  • Loc: 79355
Preferred Names
baseplate hub subunit and tail lysozyme
NP_049757.1
  • gp5; structural virion protein; in bacteriophage T4 and related viruses, the virion is composed of head and tail components; the capsid tail consists of a contractile outer sheath, a inner tube, and a baseplate; the baseplate consists of a hub surrounded by six wedges; gp5 is a component of the hub; during infection, gp5 helps to digest the peptidoglycan layer of the bacterial cell, so that the DNA can be injected into the host cell

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000866.4 Reference assembly

    Range
    77959..79686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_049757.1 baseplate hub subunit and tail lysozyme [Escherichia phage T4]

    See identical proteins and their annotated locations for NP_049757.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P16009
    UniProtKB/TrEMBL
    A0A097J7E1, A0A097J832, A0A7S9SVH6, D9IEH9
    Conserved Domains (1) summary
    PHA02596
    Location:2 → 575
    5; baseplate hub subunit and tail lysozyme; Provisional
Nucleotide Protein
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