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motA MotA-like activator of middle period transcription [ Escherichia phage T4 ]

Gene ID: 1258740, updated on 16-Jun-2026
Gene symbol
motA
Gene description
MotA-like activator of middle period transcription
Locus tag
T4p262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia phage T4 (nat-host: Escherichia coli)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Straboviridae; Tevenvirinae; Tequatrovirus
Also known as
sip
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Sequence:
NC_000866.4 (162967..163602, complement)

NC_000866.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Arn.3 conserved hypothetical protein Neighboring gene Arn.4 conserved hypothetical protein Neighboring gene MotA.1 hypothetical predicted periplasmic protein Neighboring gene DNA topoisomerase II Neighboring gene gp52.1 conserved hypothetical predicted membrane protein Neighboring gene Ac acridine resistance protein

Genomic Sequence:
NC_000866.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA. Cuypers MG, et al. Nucleic Acids Res, 2018 Jun 1. PMID 29718457, Free PMC Article
  2. Structural basis of σ appropriation. Shi J, et al. Nucleic Acids Res, 2019 Sep 26. PMID 31392983, Free PMC Article
  3. Direct activator/co-activator interaction is essential for bacteriophage T4 middle gene expression. Yuan AH, et al. Mol Microbiol, 2009 Nov. PMID 19843221, Free PMC Article
  4. A basic/hydrophobic cleft of the T4 activator MotA interacts with the C-terminus of E.coli sigma70 to activate middle gene transcription. Bonocora RP, et al. Mol Microbiol, 2008 Jul. PMID 18485078, Free PMC Article
  5. Transcriptional takeover by sigma appropriation: remodelling of the sigma70 subunit of Escherichia coli RNA polymerase by the bacteriophage T4 activator MotA and co-activator AsiA. Hinton DM, et al. Microbiology (Reading), 2005 Jun. PMID 15941982

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we report a single-particle cryo-electron microscopy (cryo-EM) structure of an intact sigma appropriation complex, comprising AsiA, MotA, Escherichia coli RNA polymerase (RNAP), sigma70 and a T4 middle promoter
    Title: Structural basis of σ appropriation.
  2. The crystal structure reveals MotA interaction with DNA and its binding motif.
    Title: The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA.
  3. The authors show that AsiA also plays a direct role in T4 middle promoter activation by contacting the MotA activation domain.
    Title: Direct activator/co-activator interaction is essential for bacteriophage T4 middle gene expression.
  4. MotA uses a 'basic/hydrophobic' cleft to interact with the C-terminus of AsiA-remodelled sigma(70), but MotA does not interact with AsiA itself.
    Title: A basic/hydrophobic cleft of the T4 activator MotA interacts with the C-terminus of E.coli sigma70 to activate middle gene transcription.
  5. review summarizes interactions of AsiA and MotA with sigma(70) and discusses how these interactions accomplish the switch to T4 middle promoters [review]
    Title: Transcriptional takeover by sigma appropriation: remodelling of the sigma70 subunit of Escherichia coli RNA polymerase by the bacteriophage T4 activator MotA and co-activator AsiA.
Submit: New GeneRIF Correction

Homology

Preferred Names
MotA-like activator of middle period transcription

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000866.4 Reference assembly

    Range
    162967..163602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_049873.1 MotA-like activator of middle period transcription [Escherichia phage T4]

    See identical proteins and their annotated locations for NP_049873.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P22915
    Conserved Domains (2) summary
    pfam09158
    Location:106 → 208
    MotCF; Bacteriophage T4 MotA, C-terminal
    pfam09114
    Location:2 → 96
    MotA_activ; Transcription factor MotA, activation domain
Nucleotide Protein
Heading Accession and Version

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