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frd dihydrofolate reductase [ Escherichia phage T4 ]

Gene ID: 1258671, updated on 18-Aug-2023
Gene symbol
frd
Gene description
dihydrofolate reductase
Locus tag
T4p239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia phage T4 (nat-host: Escherichia coli)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Straboviridae; Tevenvirinae; Tequatrovirus
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Sequence:
NC_000866.4 (145109..145690, complement)

NC_000866.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene NrdA.2 conserved hypothetical protein Neighboring gene thymidylate synthase Neighboring gene homing endonuclease Neighboring gene DUF5417 domain-containing protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000866.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Bacteriophage T4 genome. Miller ES, et al. Microbiol Mol Biol Rev, 2003 Mar. PMID 12626685, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Preferred Names
dihydrofolate reductase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000866.4 Reference assembly

    Range
    145109..145690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_049850.1 dihydrofolate reductase [Escherichia phage T4]

    See identical proteins and their annotated locations for NP_049850.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P04382
    UniProtKB/TrEMBL
    A0A097J7K9, A0A097J8B5, A0A7S9XEY2, D9IES3
    Conserved Domains (1) summary
    cl17279
    Location:23 → 183
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1JUV_A.1

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Molecular Biology Databases