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Cdkn2d cyclin dependent kinase inhibitor 2D [ Mus musculus (house mouse) ]

Gene ID: 12581, updated on 10-Oct-2024

Summary

Official Symbol
Cdkn2dprovided by MGI
Official Full Name
cyclin dependent kinase inhibitor 2Dprovided by MGI
Primary source
MGI:MGI:105387
See related
Ensembl:ENSMUSG00000096472 AllianceGenome:MGI:105387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p19; INK4d; p19INK4d
Summary
Enables protein kinase binding activity. Acts upstream of or within negative regulation of cell cycle G1/S phase transition and sensory perception of sound. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including central nervous system; genitourinary system; liver lobe; retina; and trigeminal nerve. Orthologous to human CDKN2D (cyclin dependent kinase inhibitor 2D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 73.0), liver E14.5 (RPKM 39.0) and 27 other tissues See more
Orthologs
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Genomic context

See Cdkn2d in Genome Data Viewer
Location:
9 A3; 9 7.76 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21199759..21202553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21288459..21291421, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr9:21069491-21069792 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene adaptor protein complex AP-1, mu 2 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21125421-21125608 Neighboring gene predicted gene, 39302 Neighboring gene solute carrier family 44, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA synthesis involved in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell cycle G1/S phase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV IEA
Inferred from Electronic Annotation
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of cyclin D2-CDK4 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 4 inhibitor D
Names
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
p19-INK4d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409664.1NP_001396593.1  cyclin-dependent kinase 4 inhibitor D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122525
    UniProtKB/Swiss-Prot
    Q60773, Q60794, Q91YV3
    Related
    ENSMUSP00000149499.2, ENSMUST00000213407.2
  2. NM_001409665.1NP_001396594.1  cyclin-dependent kinase 4 inhibitor D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122525
  3. NM_001409666.1NP_001396595.1  cyclin-dependent kinase 4 inhibitor D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122525
  4. NM_009878.4NP_034008.2  cyclin-dependent kinase 4 inhibitor D isoform 1

    See identical proteins and their annotated locations for NP_034008.2

    Status: VALIDATED

    Source sequence(s)
    AC122525
    Consensus CDS
    CCDS22901.1
    UniProtKB/Swiss-Prot
    Q60773, Q60794, Q91YV3
    UniProtKB/TrEMBL
    A0A1L1SRJ2
    Related
    ENSMUSP00000150701.2, ENSMUST00000215619.2
    Conserved Domains (3) summary
    PLN03192
    Location:966
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:4171
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:50136
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21199759..21202553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)