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Cdkn2c cyclin dependent kinase inhibitor 2C [ Mus musculus (house mouse) ]

Gene ID: 12580, updated on 8-Feb-2024

Summary

Official Symbol
Cdkn2cprovided by MGI
Official Full Name
cyclin dependent kinase inhibitor 2Cprovided by MGI
Primary source
MGI:MGI:105388
See related
Ensembl:ENSMUSG00000028551 AllianceGenome:MGI:105388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p18; INK4c; p18-INK6; p18INK4c; p18-INK4c
Summary
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]
Expression
Broad expression in testis adult (RPKM 24.9), subcutaneous fat pad adult (RPKM 21.7) and 24 other tissues See more
Orthologs
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Genomic context

See Cdkn2c in Genome Data Viewer
Location:
4 C7; 4 51.32 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109518073..109523953, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109660876..109666756, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630013D21 gene Neighboring gene predicted gene, 40227 Neighboring gene Fas-associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_11075 Neighboring gene STARR-seq mESC enhancer starr_11076 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene doublesex and mab-3 related transcription factor like family A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 4 inhibitor C
Names
cyclin-dependent kinase 6 inhibitor
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301368.1NP_001288297.1  cyclin-dependent kinase 4 inhibitor C

    See identical proteins and their annotated locations for NP_001288297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as p18(L)) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA189303, AK003933, AL627392, BG085472
    Consensus CDS
    CCDS18467.1
    UniProtKB/Swiss-Prot
    Q60772
    UniProtKB/TrEMBL
    Q3U054, Q9D153
    Related
    ENSMUSP00000095534.4, ENSMUST00000097921.10
    Conserved Domains (2) summary
    cd00204
    Location:37156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3767
    ANK; ANK repeat [structural motif]
  2. NM_007671.3NP_031697.1  cyclin-dependent kinase 4 inhibitor C

    See identical proteins and their annotated locations for NP_031697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as p18(S)) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA189303, AK003933, AL627392, BF657811
    Consensus CDS
    CCDS18467.1
    UniProtKB/Swiss-Prot
    Q60772
    UniProtKB/TrEMBL
    Q3U054, Q9D153
    Related
    ENSMUSP00000070313.5, ENSMUST00000063531.5
    Conserved Domains (2) summary
    cd00204
    Location:37156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3767
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109518073..109523953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)