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DIPK1C divergent protein kinase domain 1C [ Homo sapiens (human) ]

Gene ID: 125704, updated on 13-Mar-2020

Summary

Official Symbol
DIPK1Cprovided by HGNC
Official Full Name
divergent protein kinase domain 1Cprovided by HGNC
Primary source
HGNC:HGNC:31729
See related
Ensembl:ENSG00000187773 MIM:614544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM69C; C18orf51
Summary
This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]
Expression
Biased expression in brain (RPKM 3.7), testis (RPKM 1.4) and 3 other tissues See more
Orthologs

Genomic context

See DIPK1C in Genome Data Viewer
Location:
18q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (74435728..74464646, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72102963..72125070, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene FAU pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1922 Neighboring gene CRISPRi-validated cis-regulatory element chr18.1476 Neighboring gene carnosine dipeptidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
divergent protein kinase domain 1C
Names
family with sequence similarity 69 member C
protein FAM69C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044369.2NP_001037834.2  divergent protein kinase domain 1C

    See identical proteins and their annotated locations for NP_001037834.2

    Status: VALIDATED

    Source sequence(s)
    AC009704, AI375747
    Consensus CDS
    CCDS42445.2
    UniProtKB/Swiss-Prot
    Q0P6D2
    Related
    ENSP00000344331.6, ENST00000343998.7
    Conserved Domains (2) summary
    pfam12260
    Location:187385
    PIP49_C; Protein-kinase domain of FAM69
    pfam14875
    Location:24168
    PIP49_N; N-term cysteine-rich ER, FAM69

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    74435728..74464646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025551.2XP_016881040.1  divergent protein kinase domain 1C isoform X2

  2. XM_011525816.3XP_011524118.1  divergent protein kinase domain 1C isoform X1

    Conserved Domains (2) summary
    pfam12260
    Location:149347
    PIP49_C; Protein-kinase domain of FAM69
    pfam14875
    Location:28130
    PIP49_N; N-term cysteine-rich ER, FAM69

RNA

  1. XR_001753141.1 RNA Sequence

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