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Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [ Mus musculus (house mouse) ]

Gene ID: 12569, updated on 8-Dec-2022

Summary

Official Symbol
Cdk5r1provided by MGI
Official Full Name
cyclin-dependent kinase 5, regulatory subunit 1 (p35)provided by MGI
Primary source
MGI:MGI:101764
See related
Ensembl:ENSMUSG00000048895 AllianceGenome:MGI:101764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p25; p35; Cdk5r; D11Bwg0379e
Summary
Enables several functions, including Hsp90 protein binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and enzyme binding activity. Involved in several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of cytoskeleton organization. Acts upstream of or within several processes, including G1 to G0 transition involved in cell differentiation; nervous system development; and serine phosphorylation of STAT protein. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Cdk5r1 in Genome Data Viewer
Location:
11 B5; 11 47.94 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80367849..80372010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80477023..80481184)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 207 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Neighboring gene RIKEN cDNA C030013C21 gene Neighboring gene predicted gene, 53690 Neighboring gene myosin ID

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin filament binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables cytoskeletal protein binding TAS
Traceable Author Statement
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G1 to G0 transition involved in cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellum development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
 
involved_in ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within layer formation in cerebral cortex IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within serine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within superior olivary nucleus maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in contractile fiber ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase 5 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of protein kinase 5 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 5 activator 1
Names
CDK5 activator 1
TPKII regulatory subunit
cyclin-dependent kinase 5 regulatory subunit 1
cyclin-dependent kinase 5, regulatory subunit (p35) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009871.3NP_034001.1  cyclin-dependent kinase 5 activator 1

    See identical proteins and their annotated locations for NP_034001.1

    Status: VALIDATED

    Source sequence(s)
    AK142868, BC046823
    Consensus CDS
    CCDS25134.1
    UniProtKB/Swiss-Prot
    P61809, Q62938
    UniProtKB/TrEMBL
    A0A6P5QWA1, A0A8C6GMA5, Q542T9
    Related
    ENSMUSP00000099514.5, ENSMUST00000053413.12
    Conserved Domains (1) summary
    pfam03261
    Location:20293
    CDK5_activator; Cyclin-dependent kinase 5 activator protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80367849..80372010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)