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Cdk2 cyclin dependent kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 12566, updated on 12-May-2024

Summary

Official Symbol
Cdk2provided by MGI
Official Full Name
cyclin dependent kinase 2provided by MGI
Primary source
MGI:MGI:104772
See related
Ensembl:ENSMUSG00000025358 AllianceGenome:MGI:104772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630093N05Rik
Summary
Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in peptidyl-serine phosphorylation and positive regulation of cell population proliferation. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of cellular macromolecule biosynthetic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; integumental system; and limb. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 35.9), thymus adult (RPKM 24.5) and 25 other tissues See more
Orthologs
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Genomic context

See Cdk2 in Genome Data Viewer
Location:
10 D3; 10 77.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128533807..128540920, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128697938..128705051, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2343 Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E50 Neighboring gene STARR-positive B cell enhancer ABC_E2974 Neighboring gene premelanosome protein Neighboring gene diacylglycerol kinase, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5201 Neighboring gene STARR-seq mESC enhancer starr_28299 Neighboring gene STARR-positive B cell enhancer ABC_E10661 Neighboring gene STARR-seq mESC enhancer starr_28300 Neighboring gene predicted gene, 31504 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene ribosomal protein SA, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
located_in X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in Y chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin A1-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin A2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin A2-CDK2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin E1-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin E2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 2
Names
cell division protein kinase 2
NP_058036.1
NP_904326.1
XP_006513225.1
XP_011241623.1
XP_030100713.1
XP_030100714.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428414.1NP_001415343.1  cyclin-dependent kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117232
  2. NM_001428415.1NP_001415344.1  cyclin-dependent kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117232
  3. NM_001428416.1NP_001415345.1  cyclin-dependent kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117232
  4. NM_001428417.1NP_001415346.1  cyclin-dependent kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117232
  5. NM_016756.5NP_058036.1  cyclin-dependent kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_058036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC117232
    Consensus CDS
    CCDS24288.1
    UniProtKB/TrEMBL
    Q3U307, Q3U6X7
    Related
    ENSMUSP00000026415.8, ENSMUST00000026415.9
    Conserved Domains (1) summary
    cd07860
    Location:3286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
  6. NM_183417.4NP_904326.1  cyclin-dependent kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_904326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC117232
    Consensus CDS
    CCDS24289.1
    UniProtKB/Swiss-Prot
    O55105, P97377
    UniProtKB/TrEMBL
    Q3U307, Q3UGB9
    Related
    ENSMUSP00000026416.8, ENSMUST00000026416.15
    Conserved Domains (1) summary
    cd07860
    Location:3334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

RNA

  1. NR_190343.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117232
  2. NR_190344.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117232

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128533807..128540920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243321.4XP_011241623.1  cyclin-dependent kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1244
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030244853.2XP_030100713.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1196
    PKc_like; Protein Kinases, catalytic domain
  3. XM_030244854.1XP_030100714.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1196
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006513162.3XP_006513225.1  cyclin-dependent kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1244
    PKc_like; Protein Kinases, catalytic domain