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Cdh5 cadherin 5 [ Mus musculus (house mouse) ]

Gene ID: 12562, updated on 12-May-2024

Summary

Official Symbol
Cdh5provided by MGI
Official Full Name
cadherin 5provided by MGI
Primary source
MGI:MGI:105057
See related
Ensembl:ENSMUSG00000031871 AllianceGenome:MGI:105057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
7B4; Vec; VECD; Cd144; VEcad; VE-Cad
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
Expression
Biased expression in lung adult (RPKM 243.6), subcutaneous fat pad adult (RPKM 72.5) and 8 other tissues See more
Orthologs
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Genomic context

See Cdh5 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (104828247..104871136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104101613..104144504)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22502 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene, 53450 Neighboring gene STARR-positive B cell enhancer ABC_E6675 Neighboring gene predicted gene, 29682 Neighboring gene STARR-positive B cell enhancer ABC_E8849 Neighboring gene brain expressed, associated with Nedd4, 1 Neighboring gene predicted gene 10631 Neighboring gene predicted gene 45750

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell adhesion IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin-5
Names
7B4/cadherin-5
VE-cadherin
vascular endothelial cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009868.4NP_033998.2  cadherin-5 preproprotein

    See identical proteins and their annotated locations for NP_033998.2

    Status: REVIEWED

    Source sequence(s)
    BC054790, BP768525, BY078746
    Consensus CDS
    CCDS22572.1
    UniProtKB/Swiss-Prot
    O35542, P55284
    UniProtKB/TrEMBL
    Q3TJ23
    Related
    ENSMUSP00000034339.9, ENSMUST00000034339.10
    Conserved Domains (3) summary
    cd11304
    Location:153252
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:77147
    CA; Cadherin repeats
    pfam01049
    Location:626777
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    104828247..104871136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530630.2XP_006530693.1  cadherin-5 isoform X1

    See identical proteins and their annotated locations for XP_006530693.1

    UniProtKB/Swiss-Prot
    O35542, P55284
    UniProtKB/TrEMBL
    Q3TJ23
    Conserved Domains (3) summary
    cd11304
    Location:153252
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:77147
    CA; Cadherin repeats
    pfam01049
    Location:626777
    Cadherin_C; Cadherin cytoplasmic region