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Cdh13 cadherin 13 [ Mus musculus (house mouse) ]

Gene ID: 12554, updated on 9-Sep-2018

Summary

Official Symbol
Cdh13provided by MGI
Official Full Name
cadherin 13provided by MGI
Primary source
MGI:MGI:99551
See related
Ensembl:ENSMUSG00000031841 Vega:OTTMUSG00000031307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdht; Tcad; 4932416G01Rik
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
Expression
Broad expression in heart adult (RPKM 39.2), CNS E18 (RPKM 17.5) and 16 other tissues See more
Orthologs

Genomic context

See Cdh13 in Genome Data Viewer
Location:
8 E1; 8 65.97 cM
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (118140017..119324929)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (120807655..121847348)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene M phase phosphoprotein 6 Neighboring gene predicted gene, 39262 Neighboring gene predicted gene, 31893 Neighboring gene predicted gene 45723 Neighboring gene heat shock factor binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
adiponectin binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
localization within membrane ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle mediated signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin-13
Names
H-cadherin
T-cadherin
heart cadherin
NP_062681.2
XP_006530691.2
XP_011246597.1
XP_017168039.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019707.5NP_062681.2  cadherin-13 preproprotein

    See identical proteins and their annotated locations for NP_062681.2

    Status: REVIEWED

    Source sequence(s)
    AI550332, AK048724, AV343697, BB075948, BM944611, CF735928, CX242668
    Consensus CDS
    CCDS52682.1
    UniProtKB/Swiss-Prot
    Q9WTR5
    Related
    ENSMUSP00000113527.1, OTTMUSP00000041043, ENSMUST00000117160.1, OTTMUST00000077554
    Conserved Domains (4) summary
    cd11304
    Location:488581
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:161243
    CA; Cadherin repeats
    pfam00028
    Location:368469
    Cadherin; Cadherin domain
    pfam08758
    Location:26112
    Cadherin_pro; Cadherin prodomain like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    118140017..119324929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312550.1XP_017168039.1  cadherin-13 isoform X2

  2. XM_006530628.3XP_006530691.2  cadherin-13 isoform X1

    Conserved Domains (4) summary
    cd11304
    Location:475568
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:148230
    CA; Cadherin repeats
    pfam00028
    Location:355456
    Cadherin; Cadherin domain
    pfam08758
    Location:1399
    Cadherin_pro; Cadherin prodomain like
  3. XM_011248295.1XP_011246597.1  cadherin-13 isoform X3

    Conserved Domains (4) summary
    cd11304
    Location:467560
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:140222
    CA; Cadherin repeats
    pfam00028
    Location:347448
    Cadherin; Cadherin domain
    cl07391
    Location:3291
    Cadherin_pro; Cadherin prodomain like
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