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corA MIT family Mg2+/Ni2+/Co2+ transport protein [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1255478, updated on 6-Oct-2023

Summary

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Gene symbol
corA
Gene description
MIT family Mg2+/Ni2+/Co2+ transport protein
Locus tag
STM3952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Genomic context

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Sequence:
NC_003197.2 (4158073..4159138)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene putative site-specific integrase/recombinase Neighboring gene putative hydrolase of the HAD superfamily Neighboring gene DNA-dependent ATPase I and helicase II Neighboring gene putative inner membrane protein Neighboring gene putative inner membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of CorA Mg2+ channel function affects the virulence of Salmonella enterica serovar typhimurium. Papp-Wallace KM, et al. J Bacteriol, 2008 Oct. PMID 18676666, Free PMC Article
  2. The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium. Papp-Wallace KM, et al. J Bacteriol, 2008 Oct. PMID 18676664, Free PMC Article
  3. The CorA Mg2+ transporter does not transport Fe2+. Papp KM, et al. J Bacteriol, 2004 Nov. PMID 15516579, Free PMC Article
  4. The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals. Kriner MA, et al. J Mol Biol, 2015 Dec 4. PMID 26523680, Free PMC Article
  5. Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica. Cromie MJ, et al. J Bacteriol, 2010 Jan. PMID 19897653, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Mg(2+) channel gene corA in Salmonella enterica serovar Typhimurium is regulated by a Rho-dependent terminator located within its 5' leader region.
    Title: The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals.
  2. Overexpression of the Mg(2+) transporter CorA, which is believed to increase cytoplasmic Mg(2+) levels, decreased mgtA transcription in a manner dependent on a functional mgtA 5' leader.
    Title: Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica.
  3. Data show that loss of the CorA protein disrupts a regulatory network(s) with the ultimate phenotype of decreased virulence
    Title: Regulation of CorA Mg2+ channel function affects the virulence of Salmonella enterica serovar typhimurium.
  4. Data show that a corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells
    Title: The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium.
  5. affects lactoperoxidase sensitivity but not other oxidative stress
    Title: CorA affects tolerance of Escherichia coli and Salmonella enterica serovar Typhimurium to the lactoperoxidase enzyme system but not to other forms of oxidative stress.
  6. does not transport Fe2+ and that the relationship, if any, between iron toxicity and corA is indirect
    Title: The CorA Mg2+ transporter does not transport Fe2+.
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General gene information

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regulatory

  • Loc: 4158073-4158081 regulatory_class = minus_35_signal
  • Loc: 4158100-4158108 regulatory_class = minus_10_signal
  • Loc: 4158182-4158187 regulatory_class = ribosome_binding_site

General protein information

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Preferred Names
MIT family Mg2+/Ni2+/Co2+ transport protein
NP_462837.1
  • Mg transport system I; magnesium and cobalt transport protein CORA. (SW:CORA_SALTY)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    4158073..4159138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_462837.1 MIT family Mg2+/Ni2+/Co2+ transport protein [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_462837.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5I3IA85, A0A5V1IPC3, A0A6X9B423, A0A738AGE4, A0A746TXX6, A0A8F2U5T2
    Conserved Domains (1) summary
    PRK11085
    Location:1 → 316
    PRK11085; magnesium/cobalt transporter CorA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0A2R8.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases