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Cdc37 cell division cycle 37 [ Mus musculus (house mouse) ]

Gene ID: 12539, updated on 8-Feb-2024

Summary

Official Symbol
Cdc37provided by MGI
Official Full Name
cell division cycle 37provided by MGI
Primary source
MGI:MGI:109531
See related
Ensembl:ENSMUSG00000019471 AllianceGenome:MGI:109531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p50; p50Cdc37
Summary
Enables Hsp90 protein binding activity and kinase binding activity. Contributes to protein kinase regulator activity. Involved in positive regulation of mitophagy in response to mitochondrial depolarization; posttranscriptional regulation of gene expression; and regulation of protein kinase activity. Located in cytosol. Part of HSP90-CDC37 chaperone complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 68.6), liver E14 (RPKM 50.3) and 28 other tissues See more
Orthologs
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Genomic context

See Cdc37 in Genome Data Viewer
Location:
9 A3; 9 7.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21050727..21061230, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21139431..21149934, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38431 Neighboring gene microRNA 7082 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E459 Neighboring gene tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1780 Neighboring gene STARR-positive B cell enhancer ABC_E2282 Neighboring gene STARR-positive B cell enhancer ABC_E5054 Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:20966019-20966202 Neighboring gene predicted gene, 39301 Neighboring gene phosphodiesterase 4A, cAMP specific

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of HSP90-CDC37 chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of HSP90-CDC37 chaperone complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hsp90 co-chaperone Cdc37
Names
cell division cycle 37 homolog
hsp90 chaperone protein kinase-targeting subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378796.1NP_001365725.1  hsp90 co-chaperone Cdc37 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163637
    UniProtKB/TrEMBL
    A0A1L1STC0
    Related
    ENSMUSP00000150265.2, ENSMUST00000215296.2
    Conserved Domains (3) summary
    smart01071
    Location:1127
    CDC37_N; Cdc37 N terminal kinase binding
    smart01069
    Location:337427
    CDC37_C; Cdc37 C terminal domain
    smart01070
    Location:183325
    CDC37_M; Cdc37 Hsp90 binding domain
  2. NM_016742.5NP_058022.1  hsp90 co-chaperone Cdc37 isoform 2

    See identical proteins and their annotated locations for NP_058022.1

    Status: VALIDATED

    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS22894.1
    UniProtKB/Swiss-Prot
    Q3TGP0, Q61081
    UniProtKB/TrEMBL
    A0A1L1STC0
    Related
    ENSMUSP00000019615.10, ENSMUST00000019615.11
    Conserved Domains (3) summary
    smart01071
    Location:1128
    CDC37_N; Cdc37 N terminal kinase binding
    smart01069
    Location:288378
    CDC37_C; Cdc37 C terminal domain
    smart01070
    Location:134276
    CDC37_M; Cdc37 Hsp90 binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21050727..21061230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)