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motB enables flagellar motor rotation [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1253443, updated on 17-Dec-2024

Summary

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Gene symbol
motB
Gene description
enables flagellar motor rotation
Locus tag
STM1922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Genomic context

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Sequence:
NC_003197.2 (2019195..2020132, complement)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene methyl accepting chemotaxis protein II Neighboring gene purine-binding chemotaxis protein Neighboring gene sensory histitine protein kinase Neighboring gene proton conductor component of motor Neighboring gene regulator of flagellar biosynthesis Neighboring gene regulator of flagellar biosynthesis Neighboring gene putative cytoplasmic protein Neighboring gene putative universal stress protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GFP Fusion to the N-Terminus of MotB Affects the Proton Channel Activity of the Bacterial Flagellar Motor in Salmonella. Morimoto YV, et al. Biomolecules, 2020 Aug 29. PMID 32872412, Free PMC Article
  2. The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx. Kojima S, et al. Structure, 2018 Apr 3. PMID 29576320
  3. Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB. Kojima S, et al. Mol Microbiol, 2009 Aug. PMID 19627504
  4. Suppressor analysis of the MotB(D33E) mutation to probe bacterial flagellar motor dynamics coupled with proton translocation. Che YS, et al. J Bacteriol, 2008 Oct. PMID 18723617, Free PMC Article
  5. Characterization of the periplasmic domain of MotB and implications for its role in the stator assembly of the bacterial flagellar motor. Kojima S, et al. J Bacteriol, 2008 May. PMID 18310339, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GFP Fusion to the N-Terminus of MotB Affects the Proton Channel Activity of the Bacterial Flagellar Motor in Salmonella.
    Title: GFP Fusion to the N-Terminus of MotB Affects the Proton Channel Activity of the Bacterial Flagellar Motor in Salmonella.
  2. A dynamic helix rearrangement in the peptidoglycan-binding domain of MotB occurs upon activation.
    Title: The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.
  3. results suggest that the MotA/B complex is a load-sensitive proton channel that efficiently couples proton translocation with the conformational changes that generate torque
    Title: Load-sensitive coupling of proton translocation and torque generation in the bacterial flagellar motor.
  4. The proton-conductivity of a Salmonella MotA/B complex not incorporated into the motor is two orders of magnitude lower than that of a complex that is incorporated and activated.
    Title: Proton-conductivity assay of plugged and unplugged MotA/B proton channel by cytoplasmic pHluorin expressed in Salmonella.
  5. MotBC dimer formation is crucial to functional stator formation. Dimerization through the PGB domain is essential for proper arrangement of the proton channel.
    Title: Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB.
  6. These results suggest that second-site mutations recover a torque generation step involving stator-rotor interactions coupled with protonation/deprotonation of Glu-33 but not the maximum proton conductivity of MutB.
    Title: Suppressor analysis of the MotB(D33E) mutation to probe bacterial flagellar motor dynamics coupled with proton translocation.
  7. MotB(C) dimer domain plays an important role in targeting and stable anchoring of the MotA/MotB complex to putative stator-
    Title: Characterization of the periplasmic domain of MotB and implications for its role in the stator assembly of the bacterial flagellar motor.
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General gene information

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regulatory

  • Loc: c2019201-2019196 regulatory_class = ribosome_binding_site
  • Loc: c2020132-2020127 regulatory_class = ribosome_binding_site

General protein information

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Preferred Names
enables flagellar motor rotation
NP_460879.1
  • linking torque machinery to cell wall; chemotaxisMOTB protein. (SW:MOTB_SALTY)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    2019195..2020132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_460879.1 enables flagellar motor rotation [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_460879.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3Z2NZ32, A0A3Z4U7U7, A0A447NRW1, A0A5I0NZH6, A0A5U1RU20, A0A5U3KXL5, A0A5W1Z2Y1, A0A703STE3, A0A712BUP4, A0A721YLW4, A0A734GUN3, A0A741GJB5, A0A741L7L8, A0A747SPM5, A0A748CMT6, A0A757KNF6, A0A761EAV0, A0A761QMN0
    Conserved Domains (1) summary
    PRK09041
    Location:1 → 309
    motB; motility protein MotB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55892.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials