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Cdk1 cyclin-dependent kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 12534, updated on 9-Mar-2023

Summary

Official Symbol
Cdk1provided by MGI
Official Full Name
cyclin-dependent kinase 1provided by MGI
Primary source
MGI:MGI:88351
See related
Ensembl:ENSMUSG00000019942 AllianceGenome:MGI:88351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc2; Cdc2a; p34<CDC2>
Summary
Enables Hsp70 protein binding activity; chromatin binding activity; and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including mitotic G2 DNA damage checkpoint signaling; mitotic cell cycle phase transition; and protein phosphorylation. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 47.0), placenta adult (RPKM 44.1) and 11 other tissues See more
Orthologs
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Genomic context

See Cdk1 in Genome Data Viewer
Location:
10 B5.3; 10 36.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (69170976..69188742, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (69335146..69352912, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930423B08 gene Neighboring gene ribosomal protein L30, pseudogene 7 Neighboring gene suppression of tumorigenicity 13 pseudogene Neighboring gene ankyrin 3, epithelial Neighboring gene predicted gene, 51806 Neighboring gene predicted gene, 33464

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cyclin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables histone kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule cytoskeleton organization involved in mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin B1-CDK1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 1
Names
cell cycle p34 CDC2 kinase protein
cell division control protein 2 homolog
cell division cycle 2 homolog A
cell division cycle control protein 2a
cell division protein kinase 1
p34 protein kinase
NP_031685.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007659.4NP_031685.2  cyclin-dependent kinase 1

    See identical proteins and their annotated locations for NP_031685.2

    Status: VALIDATED

    Source sequence(s)
    AC131795, AK030231, BU756691
    Consensus CDS
    CCDS23908.1
    UniProtKB/Swiss-Prot
    P11440, Q3TI12
    Related
    ENSMUSP00000020099.6, ENSMUST00000020099.13
    Conserved Domains (2) summary
    PLN00009
    Location:1293
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07861
    Location:3287
    STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    69170976..69188742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)