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Cdc25c cell division cycle 25C [ Mus musculus (house mouse) ]

Gene ID: 12532, updated on 26-Sep-2022

Summary

Official Symbol
Cdc25cprovided by MGI
Official Full Name
cell division cycle 25Cprovided by MGI
Primary source
MGI:MGI:88350
See related
Ensembl:ENSMUSG00000044201 AllianceGenome:MGI:88350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc25
Summary
This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
Expression
Biased expression in CNS E11.5 (RPKM 9.4), liver E14 (RPKM 5.6) and 11 other tissues See more
Orthologs
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Genomic context

See Cdc25c in Genome Data Viewer
Location:
18 B1; 18 18.71 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34866046..34884644, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34732993..34751564, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CDC23 cell division cycle 23 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene RIKEN cDNA 2010110K18 gene Neighboring gene microRNA 12191 Neighboring gene family with sequence similarity 53, member C Neighboring gene predicted gene 3561

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell cycle G2/M phase transition IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
M-phase inducer phosphatase 3
Names
cell cycle phosphatase CDC25C
cell division cycle control protein 25C
dual specificity phosphatase Cdc25C
NP_033990.2
XP_006525614.1
XP_011245121.1
XP_036016849.1
XP_036016850.1
XP_036016851.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009860.3NP_033990.2  M-phase inducer phosphatase 3

    See identical proteins and their annotated locations for NP_033990.2

    Status: REVIEWED

    Source sequence(s)
    AC145591, AK141737
    Consensus CDS
    CCDS37759.1
    UniProtKB/Swiss-Prot
    P48967, Q99KG6
    UniProtKB/TrEMBL
    Q3UR74
    Related
    ENSMUSP00000055427.8, ENSMUST00000060710.9
    Conserved Domains (1) summary
    cd01530
    Location:275394
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34866046..34884644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160957.1XP_036016850.1  M-phase inducer phosphatase 3 isoform X3

    Conserved Domains (1) summary
    cd01530
    Location:89208
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  2. XM_006525551.4XP_006525614.1  M-phase inducer phosphatase 3 isoform X2

    Conserved Domains (1) summary
    cd01530
    Location:200319
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  3. XM_036160956.1XP_036016849.1  M-phase inducer phosphatase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q99KG6
    UniProtKB/TrEMBL
    Q3UR74
    Conserved Domains (1) summary
    cd01530
    Location:275394
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  4. XM_011246819.2XP_011245121.1  M-phase inducer phosphatase 3 isoform X3

    Conserved Domains (1) summary
    cd01530
    Location:89208
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  5. XM_036160958.1XP_036016851.1  M-phase inducer phosphatase 3 isoform X3

    Conserved Domains (1) summary
    cd01530
    Location:89208
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...