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slyA MarR family transcriptional regulator for hemolysin [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1252962, updated on 6-Jun-2024
Gene symbol
slyA
Gene description
MarR family transcriptional regulator for hemolysin
Locus tag
STM1444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Sequence:
NC_003197.2 (1519865..1520311)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene copper/zinc superoxide dismutase Neighboring gene putative inner membrane protein Neighboring gene putative multidrug resistance efflux pump Neighboring gene putative inner membrane protein Neighboring gene putative outer membrane lipoprotein Neighboring gene putative cytoplasmic protein

Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DNA recognition by the Salmonella enterica serovar Typhimurium transcription factor SlyA. Haider F, et al. Int Microbiol, 2008 Dec. PMID 19204896
  2. Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation. Okada N, et al. Microbiology (Reading), 2007 Feb. PMID 17259627
  3. Modulation of the regulatory activity of bacterial two-component systems by SlyA. Song H, et al. J Biol Chem, 2008 Oct 17. PMID 18678876, Free PMC Article
  4. SlyA and HilD Counteract H-NS-Mediated Repression on the ssrAB Virulence Operon of Salmonella enterica Serovar Typhimurium and Thus Promote Its Activation by OmpR. Banda MM, et al. J Bacteriol, 2019 Apr 15. PMID 30718301, Free PMC Article
  5. Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states. Dolan KT, et al. J Biol Chem, 2011 Jun 24. PMID 21550983, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data support two mechanisms adapted for the expression of ssrAB under different growth conditions. One involves the additive action of SlyA and HilD, whereas the other involves SlyA, but not HilD, to counteract H-NS-mediated repression on ssrAB, thus favoring in both cases the activation of ssrAB by OmpR.
    Title: SlyA and HilD Counteract H-NS-Mediated Repression on the ssrAB Virulence Operon of Salmonella enterica Serovar Typhimurium and Thus Promote Its Activation by OmpR.
  2. SlyA and other MarR global regulators rely more on indirect readout of DNA sequence to exert control over many genes
    Title: Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
  3. Systematic mutational analysis shows that no single base pair in the palindromic SlyA operator sequence is essential for DNA binding, and identifies amino acid residues required to allow SlyA to recognise DNA.
    Title: DNA recognition by the Salmonella enterica serovar Typhimurium transcription factor SlyA.
  4. SlyA has a role as a mediator in signal transduction from the PhoP/PhoQ system to other bacterial two-component systems in Salmonella
    Title: Modulation of the regulatory activity of bacterial two-component systems by SlyA.
  5. Residues Leu-63, Val-64, Arg-65, Leu-67, Leu-70, Arg-86 and Lys-88 are required for DNA binding, and residues Leu-12 and Leu-126 in the alpha-helices of the N- and C-terminal regions are required for dimer formation.
    Title: Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.
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regulatory

  • Loc: 1519865-1519870 regulatory_class = ribosome_binding_site
Preferred Names
MarR family transcriptional regulator for hemolysin
NP_460407.3
  • transcriptional regulator SLYA (salmolysin) (cytolysin SLYA). (SW:SLYA_SALTY)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    1519865..1520311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_460407.3 MarR family transcriptional regulator for hemolysin [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A709X7E4, A0A722FG15, A0A724CBZ8, A0A732JX81, A0A740DLZ6, A0A742ZK26
    Conserved Domains (1) summary
    PRK03573
    Location:3 → 146
    PRK03573; transcriptional regulator SlyA; Provisional
Nucleotide Protein
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