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Cd81 CD81 antigen [ Mus musculus (house mouse) ]

Gene ID: 12520, updated on 5-Mar-2024

Summary

Official Symbol
Cd81provided by MGI
Official Full Name
CD81 antigenprovided by MGI
Primary source
MGI:MGI:1096398
See related
Ensembl:ENSMUSG00000037706 AllianceGenome:MGI:1096398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tapa1; Tapa-1; Tspan28
Summary
Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of immune response; and syncytium formation by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 806.6), ovary adult (RPKM 391.5) and 25 other tissues See more
Orthologs
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Genomic context

See Cd81 in Genome Data Viewer
Location:
7 F5; 7 88.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142606487..142621667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143052750..143067930)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4987 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E6616 Neighboring gene tetraspanin 32 Neighboring gene STARR-seq mESC enhancer starr_20520 Neighboring gene STARR-positive B cell enhancer ABC_E6617 Neighboring gene STARR-seq mESC enhancer starr_20521 Neighboring gene expressed sequence R74862 Neighboring gene nonconserved acetylation island sequence M93 enhancer Neighboring gene tumor-suppressing subchromosomal transferable fragment 4 Neighboring gene VISTA enhancer mm183 Neighboring gene transient receptor potential cation channel, subfamily M, member 5 Neighboring gene STARR-seq mESC enhancer starr_20525 Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene predicted gene 28821

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in humoral immune response mediated by circulating immunoglobulin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunological synapse formation ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast fusion involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adaptive immune memory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process in the vacuole ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell motility IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macrophage migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in tetraspanin-enriched microdomain ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CD81 antigen
Names
26 kDa cell surface protein TAPA-1
target of the antiproliferative antibody 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133655.2NP_598416.1  CD81 antigen

    See identical proteins and their annotated locations for NP_598416.1

    Status: VALIDATED

    Source sequence(s)
    AK166521, BQ175686, BQ175800, BY252638
    Consensus CDS
    CCDS22038.1
    UniProtKB/Swiss-Prot
    P35762, Q91V78
    UniProtKB/TrEMBL
    Q3UWG5
    Related
    ENSMUSP00000043768.10, ENSMUST00000037941.10
    Conserved Domains (2) summary
    cd03151
    Location:113202
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9230
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142606487..142621667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)