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crl transcriptional regulator of cryptic csgA gene for curli surface fibers [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1251838, updated on 20-Feb-2025
Gene symbol
crl
Gene description
transcriptional regulator of cryptic csgA gene for curli surface fibers
Locus tag
STM0319
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Sequence:
NC_003197.2 (364517..364930)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene guanine-hypoxanthine phosphoribosyltransferase Neighboring gene putative hydrolase of the alpha/beta superfamily Neighboring gene outer membrane pore protein e (e,ic,nmpab) Neighboring gene gamma-glutamate kinase Neighboring gene gamma-glutamylphosphate reductase

Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Binding interface between the Salmonella σ(S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl. Cavaliere P, et al. Sci Rep, 2015 Sep 4. PMID 26338235, Free PMC Article
  2. Identification of conserved amino acid residues of the Salmonella sigmaS chaperone Crl involved in Crl-sigmaS interactions. Monteil V, et al. J Bacteriol, 2010 Feb. PMID 20008066, Free PMC Article
  3. Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium. Robbe-Saule V, et al. J Bacteriol, 2006 Jun. PMID 16707690, Free PMC Article
  4. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study provides the basis for further structural investigation of the sigma(S)-Crl complex.
    Title: Binding interface between the Salmonella σ(S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl.
  2. Site-directed mutagenesis of the crl gene from Salmonella enterica serovar Typhimurium and complementation of a Deltacrl mutant of Salmonella indicated that substitution of the conserved residues Y22, F53, W56, and W82 decreased Crl activity.
    Title: Identification of conserved amino acid residues of the Salmonella sigmaS chaperone Crl involved in Crl-sigmaS interactions.
  3. Purified His(6)-Crl showed that Crl directly activated sigma(S)-dependent transcription initiation at the csgD and adrA promoters.
    Title: Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium.
Submit: New GeneRIF Correction

regulatory

  • Loc: 364517-364522 regulatory_class = ribosome_binding_site
Preferred Names
transcriptional regulator of cryptic csgA gene for curli surface fibers
NP_459316.1
  • similar to E. coli transcriptional regulator of cryptic csgA gene for curli surface fibers (AAC73344.1); Blastp hit to AAC73344.1 (133 aa), 83% identity in aa 1 - 133

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    364517..364930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_459316.1 transcriptional regulator of cryptic csgA gene for curli surface fibers [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_459316.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5H7IJL9, A0A5U0DFX8, A0A5U1KJ30, A0A5Y2SIS9, A0A659SKM4, A0A6Y1NZQ5, A0A707JDM0, A0A718J7S7, A0A730ASK9, A0A731TE38, A0A749PF75, A0A754N569, A0A759LFE9, A0A762BYI7
    Conserved Domains (1) summary
    pfam07417
    Location:1 → 128
    Crl; Transcriptional regulator Crl
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7CR52.1

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