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KRT40 keratin 40 [ Homo sapiens (human) ]

Gene ID: 125115, updated on 26-Nov-2021

Summary

Official Symbol
KRT40provided by HGNC
Official Full Name
keratin 40provided by HGNC
Primary source
HGNC:HGNC:26707
See related
Ensembl:ENSG00000204889 MIM:616679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K40; KA36; CK-40
Summary
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT40 in Genome Data Viewer
Location:
17q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40977715..40987135, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39133967..39143387, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985072 Neighboring gene keratin 23 Neighboring gene keratin 39 Neighboring gene keratin associated protein 3-3 Neighboring gene keratin associated protein 3-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 40
Names
cytokeratin-40
keratin 40, type I
type I hair keratin KA36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012412.1 RefSeqGene

    Range
    5001..14421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001385217.1NP_001372146.1  keratin, type I cytoskeletal 40

    Status: REVIEWED

    Source sequence(s)
    AC007455
    Related
    ENSP00000506768.1, ENST00000684280.1
    Conserved Domains (1) summary
    pfam00038
    Location:88399
    Filament; Intermediate filament protein
  2. NM_001389244.1NP_001376173.1  keratin, type I cytoskeletal 40

    Status: REVIEWED

    Source sequence(s)
    AC007455
    Related
    ENSP00000366984.4, ENST00000377755.9
    Conserved Domains (1) summary
    pfam00038
    Location:88399
    Filament; Intermediate filament protein
  3. NM_182497.4NP_872303.2  keratin, type I cytoskeletal 40

    See identical proteins and their annotated locations for NP_872303.2

    Status: REVIEWED

    Source sequence(s)
    AC007455
    Consensus CDS
    CCDS42320.1
    UniProtKB/Swiss-Prot
    Q6A162
    Related
    ENSP00000381500.2, ENST00000398486.2
    Conserved Domains (1) summary
    pfam00038
    Location:88399
    Filament; Intermediate filament protein

RNA

  1. NR_163403.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007455

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40977715..40987135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524339.2XP_011522641.2  keratin, type I cytoskeletal 40 isoform X1

    Related
    ENSP00000434458.1, ENST00000461923.5

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    127110..136530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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