U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd53 CD53 antigen [ Mus musculus (house mouse) ]

Gene ID: 12508, updated on 26-Sep-2022

Summary

Official Symbol
Cd53provided by MGI
Official Full Name
CD53 antigenprovided by MGI
Primary source
MGI:MGI:88341
See related
Ensembl:ENSMUSG00000040747 AllianceGenome:MGI:88341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ox-44; Tspan25
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of myoblast fusion. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 20.6), mammary gland adult (RPKM 14.1) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cd53 in Genome Data Viewer
Location:
3 F2.3; 3 46.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106666177..106697465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106758861..106790149, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene choline/ethanolaminephosphotransferase 1 Neighboring gene DNA-damage regulated autophagy modulator 2 Neighboring gene ligand dependent nuclear receptor interacting factor 1 Neighboring gene olfactory receptor family 11 subfamily I member 1 Neighboring gene predicted gene, 35507

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leukocyte surface antigen CD53
Names
cell surface glycoprotein CD53

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007651.3NP_031677.1  leukocyte surface antigen CD53

    See identical proteins and their annotated locations for NP_031677.1

    Status: VALIDATED

    Source sequence(s)
    AA177409, AC117255, AK160326
    Consensus CDS
    CCDS17728.1
    UniProtKB/Swiss-Prot
    Q61451, Q61721
    UniProtKB/TrEMBL
    A0A8C6IMC6, Q3TV80, Q3U0W1
    Related
    ENSMUSP00000035781.9, ENSMUST00000038845.10
    Conserved Domains (2) summary
    cd03164
    Location:104186
    CD53_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9210
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106666177..106697465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)