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AFMID arylformamidase [ Homo sapiens (human) ]

Gene ID: 125061, updated on 21-Dec-2019

Summary

Official Symbol
AFMIDprovided by HGNC
Official Full Name
arylformamidaseprovided by HGNC
Primary source
HGNC:HGNC:20910
See related
Ensembl:ENSG00000183077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KF; FKF; KFA
Expression
Broad expression in kidney (RPKM 25.1), liver (RPKM 16.9) and 25 other tissues See more
Orthologs

Genomic context

See AFMID in Genome Data Viewer
Location:
17q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (78185102..78207702)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76183398..76203782)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene synaptogyrin 2 Neighboring gene uncharacterized LOC107985050 Neighboring gene thymidine kinase 1 Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene transmembrane protein 235

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC167063, DKFZp686F03259

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arylformamidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 
NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kynurenine formamidase
Names
KFase
N-formylkynurenine formamidase
probable arylformamidase
NP_001010982.2
NP_001138998.1
XP_011522628.1
XP_011522629.1
XP_011522630.1
XP_011522631.1
XP_011522632.1
XP_011522633.1
XP_011522634.1
XP_011522635.1
XP_011522636.1
XP_011522637.1
XP_011522638.1
XP_011522639.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010982.4NP_001010982.2  kynurenine formamidase isoform 2

    See identical proteins and their annotated locations for NP_001010982.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC087645, BC132824, BX648442
    Consensus CDS
    CCDS32750.2
    UniProtKB/Swiss-Prot
    Q63HM1
    Related
    ENSP00000386890.4, ENST00000409257.9
    Conserved Domains (1) summary
    COG0657
    Location:54262
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
  2. NM_001145526.2NP_001138998.1  kynurenine formamidase isoform 1

    See identical proteins and their annotated locations for NP_001138998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087645, BC132824, BX648442
    Consensus CDS
    CCDS45801.1
    UniProtKB/Swiss-Prot
    Q63HM1
    Related
    ENSP00000328938.5, ENST00000327898.9
    Conserved Domains (2) summary
    COG0657
    Location:54262
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:91262
    Abhydrolase; alpha/beta hydrolases

RNA

  1. NR_027083.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. A very short 57 aa open reading frame can be translated but is unlikely to be functional, and therefore this variant is presumed to be noncoding.
    Source sequence(s)
    AC087645, BC020920, BC132824
    Related
    ENST00000589256.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    78185102..78207702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524329.2XP_011522631.1  kynurenine formamidase isoform X2

    See identical proteins and their annotated locations for XP_011522631.1

    Conserved Domains (2) summary
    COG0657
    Location:7215
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:44215
    Abhydrolase; alpha/beta hydrolases
  2. XM_011524330.2XP_011522632.1  kynurenine formamidase isoform X2

    See identical proteins and their annotated locations for XP_011522632.1

    Conserved Domains (2) summary
    COG0657
    Location:7215
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:44215
    Abhydrolase; alpha/beta hydrolases
  3. XM_011524326.3XP_011522628.1  kynurenine formamidase isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:53227
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:56227
    Abhydrolase; alpha/beta hydrolases
  4. XM_011524333.2XP_011522635.1  kynurenine formamidase isoform X4

    Conserved Domains (2) summary
    COG0657
    Location:54199
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:58199
    Abhydrolase; alpha/beta hydrolases
  5. XM_011524336.2XP_011522638.1  kynurenine formamidase isoform X7

    Conserved Domains (2) summary
    COG0657
    Location:54151
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:67136
    Abhydrolase; alpha/beta hydrolases
  6. XM_011524327.2XP_011522629.1  kynurenine formamidase isoform X2

    See identical proteins and their annotated locations for XP_011522629.1

    Conserved Domains (2) summary
    COG0657
    Location:7215
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:44215
    Abhydrolase; alpha/beta hydrolases
  7. XM_011524331.2XP_011522633.1  kynurenine formamidase isoform X3

    See identical proteins and their annotated locations for XP_011522633.1

    Conserved Domains (1) summary
    cl21494
    Location:111215
    Abhydrolase; alpha/beta hydrolases
  8. XM_011524334.2XP_011522636.1  kynurenine formamidase isoform X5

  9. XM_011524335.2XP_011522637.1  kynurenine formamidase isoform X6

  10. XM_011524337.3XP_011522639.1  kynurenine formamidase isoform X8

    Conserved Domains (1) summary
    COG0657
    Location:54111
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
  11. XM_011524328.2XP_011522630.1  kynurenine formamidase isoform X2

    See identical proteins and their annotated locations for XP_011522630.1

    Conserved Domains (2) summary
    COG0657
    Location:7215
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:44215
    Abhydrolase; alpha/beta hydrolases
  12. XM_011524332.2XP_011522634.1  kynurenine formamidase isoform X3

    See identical proteins and their annotated locations for XP_011522634.1

    Conserved Domains (1) summary
    cl21494
    Location:111215
    Abhydrolase; alpha/beta hydrolases

RNA

  1. XR_934369.1 RNA Sequence

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