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Cd48 CD48 antigen [ Mus musculus (house mouse) ]

Gene ID: 12506, updated on 25-Jan-2022

Summary

Official Symbol
Cd48provided by MGI
Official Full Name
CD48 antigenprovided by MGI
Primary source
MGI:MGI:88339
See related
Ensembl:ENSMUSG00000015355 AllianceGenome:MGI:88339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCM1; BLAST; Bcm-1; BLAST1; SLAMF2; Sgp-60; BLAST-1; MEM-102; AI449234; AW610730
Summary
Predicted to enable antigen binding activity and signaling receptor activity. Acts upstream of or within T cell activation and signal transduction. Located in external side of plasma membrane. Is expressed in left lung; liver; right lung; and thymus primordium. Orthologous to human CD48 (CD48 molecule). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in spleen adult (RPKM 16.9), thymus adult (RPKM 12.5) and 13 other tissues See more
Orthologs
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Genomic context

See Cd48 in Genome Data Viewer
Location:
1 H3; 1 79.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171508989..171532825)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171681245..171705258)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173612186..173635388)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 9 Neighboring gene SLAM family member 7 Neighboring gene microRNA 7683 Neighboring gene translational machinery associated 7 homolog (S. cerevisiae), pseudogene Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mast cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in anchored component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CD48 antigen
Names
BCM1 surface antigen
HM48-1
MRC OX-45 surface antigen
SLAM family member 2
signaling lymphocytic activation molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360767.1NP_001347696.1  CD48 antigen isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC091521
    Consensus CDS
    CCDS87923.1
    Related
    ENSMUSP00000015499.8, ENSMUST00000015499.14
    Conserved Domains (1) summary
    cd05775
    Location:33124
    Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains
  2. NM_007649.5NP_031675.1  CD48 antigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_031675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091521, AK084984
    Consensus CDS
    CCDS15501.1
    UniProtKB/Swiss-Prot
    P18181
    Related
    ENSMUSP00000064241.6, ENSMUST00000068584.7
    Conserved Domains (2) summary
    smart00410
    Location:29110
    IG_like; Immunoglobulin like
    cl11960
    Location:36124
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171508989..171532825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496637.4XP_006496700.1  CD48 antigen isoform X2

  2. XM_006496636.2XP_006496699.1  CD48 antigen isoform X1

    Conserved Domains (1) summary
    cd05775
    Location:33124
    Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains
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