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TBC1D16 TBC1 domain family member 16 [ Homo sapiens (human) ]

Gene ID: 125058, updated on 24-Nov-2020

Summary

Official Symbol
TBC1D16provided by HGNC
Official Full Name
TBC1 domain family member 16provided by HGNC
Primary source
HGNC:HGNC:28356
See related
Ensembl:ENSG00000167291 MIM:616637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 12.8), kidney (RPKM 8.0) and 23 other tissues See more
Orthologs

Genomic context

See TBC1D16 in Genome Data Viewer
Location:
17q25.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (79932343..80035875, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77906142..78009657, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromobox 4 Neighboring gene long intergenic non-protein coding RNA 1979 Neighboring gene long intergenic non-protein coding RNA 1978 Neighboring gene coiled-coil domain containing 40 Neighboring gene microRNA 1268b Neighboring gene alpha glucosidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20748, MGC25062, DKFZp451F1311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TBC1 domain family member 16
Names
CTD-2529O21.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271844.2NP_001258773.1  TBC1 domain family member 16 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the 5' UTR and coding region, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC100791, BC062601
    Consensus CDS
    CCDS62353.1
    UniProtKB/Swiss-Prot
    Q8TBP0
    Related
    ENSP00000461522.1, ENST00000576768.5
    Conserved Domains (1) summary
    smart00164
    Location:58277
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. NM_001271845.2NP_001258774.1  TBC1 domain family member 16 isoform c

    See identical proteins and their annotated locations for NP_001258774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and coding region, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC100791, BC036947, BC062601
    Consensus CDS
    CCDS62351.1
    UniProtKB/Swiss-Prot
    Q8TBP0
    Related
    ENSP00000341517.7, ENST00000340848.11
    Conserved Domains (1) summary
    smart00164
    Location:62290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  3. NM_001271846.2NP_001258775.1  TBC1 domain family member 16 isoform d

    See identical proteins and their annotated locations for NP_001258775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in both UTRs and the coding region, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) is shorter and has distinct N- and C-termini, compared to isoform a.
    Source sequence(s)
    BC001525, BX092567, CR936670
    Consensus CDS
    CCDS62352.1
    UniProtKB/Swiss-Prot
    Q8TBP0
    Related
    ENSP00000458766.1, ENST00000572862.5
    Conserved Domains (1) summary
    smart00164
    Location:62272
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  4. NM_019020.4NP_061893.2  TBC1 domain family member 16 isoform a

    See identical proteins and their annotated locations for NP_061893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC100791, AC116025, BC028290, BC062601, CN361974
    Consensus CDS
    CCDS11766.1
    UniProtKB/Swiss-Prot
    Q8TBP0
    Related
    ENSP00000309794.2, ENST00000310924.7
    Conserved Domains (1) summary
    smart00164
    Location:424652
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    79932343..80035875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257050.3XP_005257107.1  TBC1 domain family member 16 isoform X5

    Conserved Domains (1) summary
    smart00164
    Location:423651
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. XM_024450579.1XP_024306347.1  TBC1 domain family member 16 isoform X2

    Conserved Domains (1) summary
    smart00164
    Location:423708
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  3. XM_011524322.2XP_011522624.1  TBC1 domain family member 16 isoform X6

    Conserved Domains (1) summary
    smart00164
    Location:419638
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  4. XM_024450580.1XP_024306348.1  TBC1 domain family member 16 isoform X3

    Conserved Domains (1) summary
    smart00164
    Location:419695
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  5. XM_006721694.3XP_006721757.1  TBC1 domain family member 16 isoform X4

    See identical proteins and their annotated locations for XP_006721757.1

    UniProtKB/Swiss-Prot
    Q8TBP0
    Conserved Domains (1) summary
    smart00164
    Location:424652
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  6. XM_024450578.1XP_024306346.1  TBC1 domain family member 16 isoform X1

    Conserved Domains (1) summary
    smart00164
    Location:424709
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  7. XM_024450576.1XP_024306344.1  TBC1 domain family member 16 isoform X1

    Conserved Domains (1) summary
    smart00164
    Location:424709
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  8. XM_024450577.1XP_024306345.1  TBC1 domain family member 16 isoform X1

    Conserved Domains (1) summary
    smart00164
    Location:424709
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  9. XM_017024187.1XP_016879676.1  TBC1 domain family member 16 isoform X10

  10. XM_024450582.1XP_024306350.1  TBC1 domain family member 16 isoform X11

    Conserved Domains (1) summary
    smart00164
    Location:53338
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  11. XM_024450581.1XP_024306349.1  TBC1 domain family member 16 isoform X7

    Conserved Domains (1) summary
    smart00164
    Location:424691
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  12. XM_017024185.1XP_016879674.1  TBC1 domain family member 16 isoform X9

  13. XM_005257052.3XP_005257109.1  TBC1 domain family member 16 isoform X8

    Conserved Domains (1) summary
    smart00164
    Location:424634
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
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