Format

Send to:

Choose Destination

GGT6 gamma-glutamyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 124975, updated on 3-Jun-2018
Official Symbol
GGT6provided by HGNC
Official Full Name
gamma-glutamyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:26891
See related
Ensembl:ENSG00000167741 MIM:612341; Vega:OTTHUMG00000177827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Expression
Biased expression in colon (RPKM 26.8), kidney (RPKM 22.6) and 12 other tissues See more
Orthologs
See GGT6 in Genome Data Viewer
Location:
17p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (4556927..4560920, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4460222..4463876, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985053 Neighboring gene sphingolipid transporter 2 Neighboring gene MYB binding protein 1a Neighboring gene thioredoxin pseudogene 4 Neighboring gene smoothelin like 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25990, FLJ90165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hypoglycin A gamma-glutamyl transpeptidase activity IEA
Inferred from Electronic Annotation
more info
 
leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
 
leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
glutathione hydrolase 6
Names
gamma-glutamyltransferase 6 homolog
gamma-glutamyltranspeptidase 6
NP_001116362.1
NP_001275631.1
NP_001275632.1
NP_001275633.1
NP_699169.2
XP_024306340.1
XP_024306341.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122890.2NP_001116362.1  glutathione hydrolase 6 isoform a

    See identical proteins and their annotated locations for NP_001116362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. It encodes isoform a, which is shorter than isoform c.
    Source sequence(s)
    AI284219, AK129501, BC063111, BM720407, DC345075
    Consensus CDS
    CCDS45582.1
    UniProtKB/Swiss-Prot
    Q6P531
    UniProtKB/TrEMBL
    Q6ZPD7
    Related
    ENSP00000458307.1, OTTHUMP00000257740, ENST00000574154.5, OTTHUMT00000439122
    Conserved Domains (1) summary
    cl19223
    Location:117388
    G_glu_transpept; Gamma-glutamyltranspeptidase
  2. NM_001288702.1NP_001275631.1  glutathione hydrolase 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AI284219, AK296645, BC063111, BM720407, BP276563, DC345075
    Consensus CDS
    CCDS73942.1
    UniProtKB/Swiss-Prot
    Q6P531
    UniProtKB/TrEMBL
    B4DKN3, J3KPJ0
    Related
    ENSP00000370962.3, OTTHUMP00000257741, ENST00000381550.7, OTTHUMT00000439123
    Conserved Domains (1) summary
    cl19223
    Location:123394
    G_glu_transpept; Gamma-glutamyltranspeptidase
  3. NM_001288703.1NP_001275632.1  glutathione hydrolase 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region and another alternate splice site in the 3' coding region, the latter resulting in a frameshift and an early stop codon, compared to variant 3. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AI284219, AK129501, AK296645, BC063111, BM720407, DA645854, DC345075, DC345192
    UniProtKB/Swiss-Prot
    Q6P531
    UniProtKB/TrEMBL
    B4DKN3, Q6ZPD7
    Related
    ENSP00000459662.1, OTTHUMP00000257743, ENST00000574584.1, OTTHUMT00000439125
    Conserved Domains (1) summary
    cl19223
    Location:107146
    G_glu_transpept; Gamma-glutamyltranspeptidase
  4. NM_001288704.1NP_001275633.1  glutathione hydrolase 6 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 3. It encodes isoform e, which is shorter and has a distinct C-terminus compared to isoform c.
    Source sequence(s)
    AI284219, AK296645, BC063111, BM720407, BP276563, CV571037, DC345075
    UniProtKB/Swiss-Prot
    Q6P531
    UniProtKB/TrEMBL
    B4DKN3
  5. NM_153338.3NP_699169.2  glutathione hydrolase 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
    Source sequence(s)
    AI284219, AK074646, AK296645, BC063111, BM720407, DC345075
    Consensus CDS
    CCDS11047.1
    UniProtKB/Swiss-Prot
    Q6P531
    UniProtKB/TrEMBL
    B4DKN3
    Related
    ENSP00000301395.3, OTTHUMP00000257739, ENST00000301395.7, OTTHUMT00000439121
    Conserved Domains (1) summary
    cl19223
    Location:146356
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    4556927..4560920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450572.1XP_024306340.1  glutathione hydrolase 6 isoform X1

    Conserved Domains (1) summary
    cl19223
    Location:242513
    G_glu_transpept; Gamma-glutamyltranspeptidase
  2. XM_024450573.1XP_024306341.1  glutathione hydrolase 6 isoform X2

    Conserved Domains (1) summary
    cl19223
    Location:232271
    G_glu_transpept; Gamma-glutamyltranspeptidase
Support Center