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Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 12495, updated on 22-Jan-2023

Summary

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Official Symbol
Entpd1provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 1provided by MGI
Primary source
MGI:MGI:102805
See related
Ensembl:ENSMUSG00000048120 AllianceGenome:MGI:102805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd39; NTPDase-1; 2610206B08Rik; E130009M23Rik
Summary
Enables adenosine-diphosphatase activity and nucleoside-triphosphatase activity. Involved in ADP catabolic process. Acts upstream of or within G protein-coupled receptor signaling pathway; platelet activation; and purine ribonucleoside diphosphate catabolic process. Located in basement membrane. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 23.6), placenta adult (RPKM 14.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Entpd1 in Genome Data Viewer
Location:
19 C3; 19 34.25 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40600810..40730046)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40612366..40741602)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 27042 Neighboring gene tectonic family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene predicted gene, 54044 Neighboring gene predicted gene, 41846 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene predicted gene, 33482 Neighboring gene cyclin J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease. Shuai C, et al. Eur J Pharmacol, 2021 Aug 15. PMID 34033815
  2. NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female. Babou Kammoe RB, et al. Biomolecules, 2021 Jan 23. PMID 33498759, Free PMC Article
  3. Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection. Peng X, et al. Transplant Proc, 2021 Jan-Feb. PMID 32773283
  4. Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP. Cui QQ, et al. EMBO Rep, 2020 Apr 3. PMID 32133764, Free PMC Article
  5. Overexpressed CD39 mitigates sepsis‑induced kidney epithelial cell injury via suppressing the activation of NLR family pyrin domain containing 3. Yang M, et al. Int J Mol Med, 2019 Nov. PMID 31545401, Free PMC Article

See all (141) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.
    Title: Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.
  2. The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
    Title: The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
  3. Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.
    Title: Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.
  4. CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
    Title: CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
  5. CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis.
    Title: CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis.
  6. NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female.
    Title: NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female.
  7. CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/beta-Catenin Pathway in Osteoporosis.
    Title: CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/β-Catenin Pathway in Osteoporosis.
  8. Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection.
    Title: Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection.
  9. Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP.
    Title: Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP.
  10. Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
    Title: Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ADP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ADP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within platelet activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within purine ribonucleoside diphosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 1
Names
CD39 antigen
NTPDase 1
ecto-ATP diphosphohydrolase 1
ecto-ATPDase 1
ecto-ATPase 1
ectoapyrase
lymphoid cell activation antigen
NP_001291650.1
NP_033978.1
XP_006526681.1
XP_006526682.1
XP_006526683.1
XP_017173536.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304721.1 → NP_001291650.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 1

    See identical proteins and their annotated locations for NP_001291650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC166063, AK029512, AK030601
    Consensus CDS
    CCDS79708.1
    UniProtKB/TrEMBL
    Q544U5, Q8CDV7
    Related
    ENSMUSP00000116285.2, ENSMUST00000134063.8
    Conserved Domains (1) summary
    pfam01150
    Location:69 → 500
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

  2. NM_009848.4 → NP_033978.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 2

    See identical proteins and their annotated locations for NP_033978.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses an alternate start codon, compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK030601, CN696192
    Consensus CDS
    CCDS50434.1
    UniProtKB/Swiss-Prot
    P55772
    UniProtKB/TrEMBL
    Q544U5
    Related
    ENSMUSP00000107850.3, ENSMUST00000112231.9
    Conserved Domains (1) summary
    pfam01150
    Location:40 → 471
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    40600810..40730046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526619.5 → XP_006526682.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526682.1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_006526620.5 → XP_006526683.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526683.1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_006526618.5 → XP_006526681.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526681.1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_017318047.2 → XP_017173536.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55772.1 GenPept UniProtKB/Swiss-Prot:P55772

Gene LinkOut

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