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SPACA3 sperm acrosome associated 3 [ Homo sapiens (human) ]

Gene ID: 124912, updated on 12-May-2019

Summary

Official Symbol
SPACA3provided by HGNC
Official Full Name
sperm acrosome associated 3provided by HGNC
Primary source
HGNC:HGNC:16260
See related
Ensembl:ENSG00000141316 MIM:612749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT54; LYC3; LYZC; LYZL3; SLLP1; ALLP17
Summary
The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward testis (RPKM 20.0) See more
Orthologs

Genomic context

See SPACA3 in Genome Data Viewer
Location:
17q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (32991864..32997877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (31318882..31324895)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724731 Neighboring gene transmembrane protein 98 Neighboring gene uncharacterized LOC105371737 Neighboring gene acid sensing ion channel subunit 2 Neighboring gene uncharacterized LOC100506677

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT lysozyme activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte activation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of macrophage activation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phagocytosis TAS
Traceable Author Statement
more info
PubMed 
sperm-egg recognition IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sperm acrosome membrane-associated protein 3
Names
cancer/testis antigen 54
lysozyme C
lysozyme-like acrosomal sperm-specific secretory protein ALLP-17
lysozyme-like protein 3
lysozyme-like sperm-specific secretory protein ALLP17
sperm lysozyme-like protein 1
sperm lyzozyme-like acrosomal protein 1
sperm protein reactive with ASA
sperm protein reactive with antisperm antibodies

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317225.1NP_001304154.1  sperm acrosome membrane-associated protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC029867
    UniProtKB/TrEMBL
    Q05C28
    Conserved Domains (1) summary
    cd00119
    Location:24119
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
  2. NM_001317226.1NP_001304155.1  sperm acrosome membrane-associated protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF216311, BF511575, BQ438507
    Consensus CDS
    CCDS82105.1
    UniProtKB/Swiss-Prot
    Q8IXA5
    UniProtKB/TrEMBL
    E9PF91
    Related
    ENSP00000378134.1, ENST00000394638.1
    Conserved Domains (1) summary
    cd00119
    Location:13108
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
  3. NM_173847.5NP_776246.1  sperm acrosome membrane-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_776246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC003687, AF216311, BF511575
    Consensus CDS
    CCDS11275.1
    UniProtKB/Swiss-Prot
    Q8IXA5
    UniProtKB/TrEMBL
    A0A080YUZ7
    Related
    ENSP00000269053.3, ENST00000269053.8
    Conserved Domains (1) summary
    cd00119
    Location:88211
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    32991864..32997877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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