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Cd28 CD28 antigen [ Mus musculus (house mouse) ]

Gene ID: 12487, updated on 14-May-2024

Summary

Official Symbol
Cd28provided by MGI
Official Full Name
CD28 antigenprovided by MGI
Primary source
MGI:MGI:88327
See related
Ensembl:ENSMUSG00000026012 AllianceGenome:MGI:88327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 17.9), spleen adult (RPKM 1.8) and 1 other tissue See more
Orthologs
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Genomic context

Location:
1 C2; 1 30.52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60785547..60812521)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60746388..60773359)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01073 Neighboring gene predicted gene, 38388 Neighboring gene predicted gene, 51626 Neighboring gene eukaryotic translation initiation factor 4A, pseudogene 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:60803123-60803306 Neighboring gene RIKEN cDNA 2310016D23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:60833855-60834049 Neighboring gene STARR-seq mESC enhancer starr_01074 Neighboring gene STARR-seq mESC enhancer starr_01075 Neighboring gene predicted gene 11609 Neighboring gene mortality factor 4 like 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8) 
  • Targeted (10)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell costimulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell costimulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of regulatory T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
T-cell-specific surface glycoprotein CD28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007642.4NP_031668.3  T-cell-specific surface glycoprotein CD28 precursor

    See identical proteins and their annotated locations for NP_031668.3

    Status: VALIDATED

    Source sequence(s)
    AK030812, AK037772, BC064058, BY225764
    Consensus CDS
    CCDS14992.1
    UniProtKB/Swiss-Prot
    P31041, Q6GSH7
    UniProtKB/TrEMBL
    Q8CDB3
    Related
    ENSMUSP00000027165.3, ENSMUST00000027165.3
    Conserved Domains (1) summary
    cl11960
    Location:22137
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    60785547..60812521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156388.1XP_036012281.1  T-cell-specific surface glycoprotein CD28 isoform X1

    UniProtKB/TrEMBL
    Q8CDB3
    Conserved Domains (2) summary
    cd00096
    Location:1620
    Ig; Ig strand A [structural motif]
    cl11960
    Location:16132
    Ig; Immunoglobulin domain