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WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Homo sapiens (human) ]

Gene ID: 124857, updated on 4-Oct-2020

Summary

Official Symbol
WFIKKN2provided by HGNC
Official Full Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by HGNC
Primary source
HGNC:HGNC:30916
See related
Ensembl:ENSG00000173714 MIM:610895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP-1; WFDC20B; hGASP-1; WFIKKNRP
Summary
The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]
Expression
Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8) See more
Orthologs

Genomic context

See WFIKKN2 in Genome Data Viewer
Location:
17q21.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50834584..50842353)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48912011..48919709)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ANKRD40 C-terminal like Neighboring gene microRNA 8059 Neighboring gene ribosomal protein L5 pseudogene 33 Neighboring gene TOB1 antisense RNA 1 Neighboring gene transducer of ERBB2, 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Names
WAP four-disulfide core domain 20B
WAP, FS, Ig, two KU and NTR module related protein
WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related protein
WFIKKN-related protein
growth and differentiation factor-associated serum protein 1
multivalent protease inhibitor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330341.2NP_001317270.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091062, AK298172, AY358142, BG197394
    Consensus CDS
    CCDS82159.1
    UniProtKB/Swiss-Prot
    Q8TEU8
    UniProtKB/TrEMBL
    C9J6G4
    Related
    ENSP00000405889.1, ENST00000426127.1
  2. NM_175575.6NP_783165.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_783165.1

    Status: REVIEWED

    Source sequence(s)
    AC091062, AF468657, AY358142, BG221308
    Consensus CDS
    CCDS11575.1
    UniProtKB/Swiss-Prot
    Q8TEU8
    Related
    ENSP00000311184.4, ENST00000311378.5
    Conserved Domains (6) summary
    cd05765
    Location:224304
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:138174
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:455563
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam07679
    Location:216304
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:385436
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:4490
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50834584..50842353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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