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Cd2 CD2 antigen [ Mus musculus (house mouse) ]

Gene ID: 12481, updated on 25-Jun-2024

Summary

Official Symbol
Cd2provided by MGI
Official Full Name
CD2 antigenprovided by MGI
Primary source
MGI:MGI:88320
See related
Ensembl:ENSMUSG00000027863 AllianceGenome:MGI:88320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly37; LFA-2; Ly-37
Summary
Enables identical protein binding activity. Predicted to be involved in T cell activation; heterotypic cell-cell adhesion; and positive regulation of cytokine production. Located in several cellular components, including cell-cell junction; cytoplasmic side of plasma membrane; and external side of plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD2 (CD2 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 30.1), spleen adult (RPKM 18.0) and 2 other tissues See more
Orthologs
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Genomic context

See Cd2 in Genome Data Viewer
Location:
3 F2.2; 3 44.17 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101183224..101195255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101275908..101287939, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_08522 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101078754-101078985 Neighboring gene STARR-seq mESC enhancer starr_08524 Neighboring gene STARR-positive B cell enhancer ABC_E4566 Neighboring gene predicted gene, 32803 Neighboring gene STARR-positive B cell enhancer ABC_E11205 Neighboring gene RAN guanine nucleotide release factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface antigen CD2
Names
LFA-3 receptor
T-cell surface antigen T11/Leu-5
lymphocyte antigen 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013486.2NP_038514.1  T-cell surface antigen CD2 precursor

    See identical proteins and their annotated locations for NP_038514.1

    Status: PROVISIONAL

    Source sequence(s)
    AC131184, AL645930
    Consensus CDS
    CCDS17681.1
    UniProtKB/Swiss-Prot
    P08920, Q61394
    UniProtKB/TrEMBL
    Q549Q4, Q9R201
    Related
    ENSMUSP00000029456.5, ENSMUST00000029456.5
    Conserved Domains (2) summary
    pfam05790
    Location:129199
    C2-set; Immunoglobulin C2-set domain
    pfam07686
    Location:25121
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    101183224..101195255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)