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Cd19 CD19 antigen [ Mus musculus (house mouse) ]

Gene ID: 12478, updated on 18-Jan-2022

Summary

Official Symbol
Cd19provided by MGI
Official Full Name
CD19 antigenprovided by MGI
Primary source
MGI:MGI:88319
See related
Ensembl:ENSMUSG00000030724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW495831
Summary
Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in spleen adult (RPKM 117.1), mammary gland adult (RPKM 26.5) and 2 other tissues See more
Orthologs
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Genomic context

See Cd19 in Genome Data Viewer
Location:
7 F3; 7 69.01 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126007620..126016401, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126408448..126415148, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133551962..133558384, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene spinster homolog 1 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Neighboring gene SH2B adaptor protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B-1 B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
B-lymphocyte antigen CD19
Names
differentiation antigen CD19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357091.1NP_001344020.1  B-lymphocyte antigen CD19 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS90327.1
    Related
    ENSMUSP00000032968.7, ENSMUST00000032968.7
    Conserved Domains (2) summary
    smart00410
    Location:183263
    IG_like; Immunoglobulin like
    cd04979
    Location:21118
    Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
  2. NM_009844.2NP_033974.2  B-lymphocyte antigen CD19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033974.2

    Status: VALIDATED

    Source sequence(s)
    AK163608, BE686865, BY234629
    Consensus CDS
    CCDS21828.1
    UniProtKB/Swiss-Prot
    P25918
    UniProtKB/TrEMBL
    Q3TQG5
    Related
    ENSMUSP00000145803.2, ENSMUST00000206325.2
    Conserved Domains (3) summary
    cd04979
    Location:21118
    Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
    smart00410
    Location:26115
    IG_like; Immunoglobulin like
    cl11960
    Location:180259
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126007620..126016401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152614.1XP_036008507.1  B-lymphocyte antigen CD19 isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:7078
    Ig; Ig strand B [structural motif]
    cl11960
    Location:65147
    Ig; Immunoglobulin domain
  2. XM_030242041.2XP_030097901.1  B-lymphocyte antigen CD19 isoform X2

  3. XM_036152615.1XP_036008508.1  B-lymphocyte antigen CD19 isoform X2

    Related
    ENSMUST00000205997.2
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