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Cd19 CD19 antigen [ Mus musculus (house mouse) ]

Gene ID: 12478, updated on 8-Feb-2024

Summary

Official Symbol
Cd19provided by MGI
Official Full Name
CD19 antigenprovided by MGI
Primary source
MGI:MGI:88319
See related
Ensembl:ENSMUSG00000030724 AllianceGenome:MGI:88319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 117.1), mammary gland adult (RPKM 26.5) and 2 other tissues See more
Orthologs
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Genomic context

See Cd19 in Genome Data Viewer
Location:
7 F3; 7 69.01 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126007620..126016401, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126408448..126415148, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133521004-133521187 Neighboring gene SPNS lysolipid transporter 1, lysophospholipid Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133540343-133540526 Neighboring gene STARR-positive B cell enhancer ABC_E8208 Neighboring gene STARR-positive B cell enhancer ABC_E9706 Neighboring gene STARR-positive B cell enhancer ABC_E9707 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133618829-133619012 Neighboring gene SH2B adaptor protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B-1 B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
B-lymphocyte antigen CD19
Names
differentiation antigen CD19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357091.2NP_001344020.1  B-lymphocyte antigen CD19 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS90327.1
    UniProtKB/TrEMBL
    A0A0X1KG58, Q3U1A5
    Related
    ENSMUSP00000032968.7, ENSMUST00000032968.7
    Conserved Domains (2) summary
    smart00410
    Location:183263
    IG_like; Immunoglobulin like
    cd04979
    Location:21118
    Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
  2. NM_009844.3NP_033974.2  B-lymphocyte antigen CD19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033974.2

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS21828.1
    UniProtKB/Swiss-Prot
    P25918, Q542B2
    UniProtKB/TrEMBL
    Q3TA95
    Related
    ENSMUSP00000145803.2, ENSMUST00000206325.2
    Conserved Domains (3) summary
    cd04979
    Location:21118
    Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
    smart00410
    Location:26115
    IG_like; Immunoglobulin like
    cl11960
    Location:180259
    Ig; Immunoglobulin domain

RNA

  1. NR_178083.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125322

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126007620..126016401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152614.1XP_036008507.1  B-lymphocyte antigen CD19 isoform X1

    UniProtKB/TrEMBL
    Q3TQG5
    Conserved Domains (2) summary
    cd00096
    Location:7078
    Ig; Ig strand B [structural motif]
    cl11960
    Location:65147
    Ig; Immunoglobulin domain
  2. XM_036152615.1XP_036008508.1  B-lymphocyte antigen CD19 isoform X2

    Related
    ENSMUST00000205997.2