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Cd14 CD14 antigen [ Mus musculus (house mouse) ]

Gene ID: 12475, updated on 18-May-2023

Summary

Official Symbol
Cd14provided by MGI
Official Full Name
CD14 antigenprovided by MGI
Primary source
MGI:MGI:88318
See related
Ensembl:ENSMUSG00000051439 AllianceGenome:MGI:88318
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]
Expression
Broad expression in mammary gland adult (RPKM 18.9), colon adult (RPKM 18.3) and 15 other tissues See more
Orthologs
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Genomic context

See Cd14 in Genome Data Viewer
Location:
18 B2; 18 19.46 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36858117..36859868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36725064..36726815, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA E230025N22 gene Neighboring gene predicted gene, 41699 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide immune receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipoteichoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell surface pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to diacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipoteichoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of lipopolysaccharide receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of lipopolysaccharide receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
monocyte differentiation antigen CD14
Names
myeloid cell-specific leucine-rich glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009841.4NP_033971.1  monocyte differentiation antigen CD14 precursor

    See identical proteins and their annotated locations for NP_033971.1

    Status: REVIEWED

    Source sequence(s)
    AC027740, AK149744, AK151139, BY498446, EH108279
    Consensus CDS
    CCDS29159.1
    UniProtKB/Swiss-Prot
    P10810
    UniProtKB/TrEMBL
    Q3UB18, Q3UE54, Q4FJP7
    Related
    ENSMUSP00000056669.7, ENSMUST00000061829.8
    Conserved Domains (3) summary
    cd00116
    Location:107303
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:192219
    LRR_1; leucine-rich repeat [structural motif]
    sd00034
    Location:114139
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36858117..36859868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)