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Cct8 chaperonin containing TCP1 subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 12469, updated on 5-Mar-2024

Summary

Official Symbol
Cct8provided by MGI
Official Full Name
chaperonin containing TCP1 subunit 8provided by MGI
Primary source
MGI:MGI:107183
See related
Ensembl:ENSMUSG00000025613 AllianceGenome:MGI:107183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cctq; Tcpq
Summary
Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida; pore complex assembly; and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 95.8), placenta adult (RPKM 88.4) and 25 other tissues See more
Orthologs
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Genomic context

See Cct8 in Genome Data Viewer
Location:
16 C3.3; 16 49.57 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87280213..87292757, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87483325..87495869, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene predicted gene, 25896 Neighboring gene STARR-positive B cell enhancer ABC_E1186 Neighboring gene STARR-positive B cell enhancer ABC_E11624 Neighboring gene RWD domain containing 2B Neighboring gene STARR-positive B cell enhancer ABC_E10922 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene RIKEN cDNA B130034C11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5556 Neighboring gene predicted gene, 24891

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit theta
Names
CCT-theta
TCP-1-theta
chaperonin containing Tcp1, subunit 8 (theta)
chaperonin subunit 8 (theta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009840.3NP_033970.3  T-complex protein 1 subunit theta

    See identical proteins and their annotated locations for NP_033970.3

    Status: VALIDATED

    Source sequence(s)
    AK075711, AK075880, AK147038, AV335786
    Consensus CDS
    CCDS37384.1
    UniProtKB/Swiss-Prot
    P42932
    UniProtKB/TrEMBL
    Q3UKQ2, Q3UL22, Q8BVY8
    Related
    ENSMUSP00000026704.8, ENSMUST00000026704.14
    Conserved Domains (2) summary
    TIGR02346
    Location:10539
    chap_CCT_theta; T-complex protein 1, theta subunit
    pfam00118
    Location:39528
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    87280213..87292757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)