U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cct7 chaperonin containing TCP1 subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 12468, updated on 1-Mar-2024

Summary

Official Symbol
Cct7provided by MGI
Official Full Name
chaperonin containing TCP1 subunit 7provided by MGI
Primary source
MGI:MGI:107184
See related
Ensembl:ENSMUSG00000030007 AllianceGenome:MGI:107184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccth; Cctz
Summary
Enables identical protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT7 (chaperonin containing TCP1 subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 177.0), CNS E11.5 (RPKM 113.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cct7 in Genome Data Viewer
Location:
6 C3; 6 37.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85428487..85445459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85451505..85468477)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene notochord homeobox Neighboring gene SET and MYND domain containing 5 Neighboring gene protease-associated domain containing 1 Neighboring gene F-box protein 41 Neighboring gene early growth response 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit eta
Names
CCT-eta
TCP-1-eta
chaperonin containing Tcp1, subunit 7 (eta)
chaperonin containing t-complex subunit eta
chaperonin subunit 7 (eta)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007638.4NP_031664.3  T-complex protein 1 subunit eta

    See identical proteins and their annotated locations for NP_031664.3

    Status: VALIDATED

    Source sequence(s)
    AC155728, AK146902, AK150160, BQ951185
    Consensus CDS
    CCDS20295.1
    UniProtKB/Swiss-Prot
    P80313
    UniProtKB/TrEMBL
    Q3TET0, Q3THH8, Q3TIJ7, Q3TJN2, Q8C5Q5
    Related
    ENSMUSP00000032078.7, ENSMUST00000032078.9
    Conserved Domains (1) summary
    cd03340
    Location:5525
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85428487..85445459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)