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Cct3 chaperonin containing TCP1 subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 12462, updated on 8-Feb-2024

Summary

Official Symbol
Cct3provided by MGI
Official Full Name
chaperonin containing TCP1 subunit 3provided by MGI
Primary source
MGI:MGI:104708
See related
Ensembl:ENSMUSG00000001416 AllianceGenome:MGI:104708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cctg; TriC-P5; Tcp1-rs3
Summary
Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida; pore complex assembly; and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including branchial arch; fronto-nasal process; and limb. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 119.9), placenta adult (RPKM 98.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cct3 in Genome Data Viewer
Location:
3 F1; 3 38.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88204442..88229073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88297135..88321766)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rhesus blood group-associated B glycoprotein Neighboring gene STARR-seq mESC enhancer starr_08178 Neighboring gene STARR-seq mESC enhancer starr_08179 Neighboring gene TSSK6 activating co-chaperone Neighboring gene glycosylated lysosomal membrane protein Neighboring gene transmembrane protein 79

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit gamma
Names
CCT-gamma
TCP-1-gamma
chaperonin containing Tcp1, subunit 3 (gamma)
chaperonin subunit 3 (gamma)
matricin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009836.1NP_033966.1  T-complex protein 1 subunit gamma

    See identical proteins and their annotated locations for NP_033966.1

    Status: PROVISIONAL

    Source sequence(s)
    Z31556
    Consensus CDS
    CCDS17468.1
    UniProtKB/Swiss-Prot
    P80318
    UniProtKB/TrEMBL
    Q3U4U6, Q3UJP4
    Related
    ENSMUSP00000001452.8, ENSMUST00000001452.14
    Conserved Domains (2) summary
    cd03337
    Location:6525
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:6529
    chap_CCT_gamma; T-complex protein 1, gamma subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88204442..88229073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)