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CD300LB CD300 molecule like family member b [ Homo sapiens (human) ]

Gene ID: 124599, updated on 8-Jul-2021

Summary

Official Symbol
CD300LBprovided by HGNC
Official Full Name
CD300 molecule like family member bprovided by HGNC
Primary source
HGNC:HGNC:30811
See related
Ensembl:ENSG00000178789 MIM:610705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2
Summary
CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in appendix (RPKM 4.4), bone marrow (RPKM 2.5) and 11 other tissues See more
Orthologs
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Genomic context

See CD300LB in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74521174..74531475, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72517313..72527614, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor class C group 5 member C Neighboring gene CD300a molecule Neighboring gene uncharacterized LOC107985074 Neighboring gene CD300c molecule Neighboring gene CD300H molecule (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CMRF35-like molecule 7
Names
CD300 antigen like family member B
immune receptor expressed on myeloid cells 3
leukocyte mono-Ig-like receptor 5
triggering receptor expressed on myeloid cells 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174892.4NP_777552.3  CMRF35-like molecule 7 precursor

    See identical proteins and their annotated locations for NP_777552.3

    Status: VALIDATED

    Source sequence(s)
    AC079325, AK290925, BC028091
    Consensus CDS
    CCDS11700.2
    UniProtKB/Swiss-Prot
    A8K4G0
    Related
    ENSP00000376397.2, ENST00000392621.6
    Conserved Domains (2) summary
    cd05716
    Location:24121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:21121
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74521174..74531475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257027.3XP_005257084.1  CMRF35-like molecule 7 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:61158
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:58158
    IG_like; Immunoglobulin like
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