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Noct nocturnin [ Mus musculus (house mouse) ]

Gene ID: 12457, updated on 5-Jan-2023

Summary

Official Symbol
Noctprovided by MGI
Official Full Name
nocturninprovided by MGI
Primary source
MGI:MGI:109382
See related
Ensembl:ENSMUSG00000023087 AllianceGenome:MGI:109382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccr4; Ccrn4l
Summary
Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly; circadian rhythm; and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 54.9), colon adult (RPKM 24.9) and 28 other tissues See more
Orthologs
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Genomic context

See Noct in Genome Data Viewer
Location:
3; 3 C
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51131868..51159075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51224447..51251654)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35891 Neighboring gene predicted gene, 40044 Neighboring gene RIKEN cDNA 4930577N17 gene Neighboring gene E74-like factor 2 Neighboring gene nuclear encoded tRNA proline 7 (anticodon TGG)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADP phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPH phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nocturnin
Names
CCR4 carbon catabolite repression 4-like
CCR4 protein homolog
carbon catabolite repression 4 homolog
carbon catabolite repression 4-like protein
circadian deadenylase NOC
NP_033964.1
XP_006501019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009834.2NP_033964.1  nocturnin

    See identical proteins and their annotated locations for NP_033964.1

    Status: VALIDATED

    Source sequence(s)
    AK084516, AK087790, BB261546
    Consensus CDS
    CCDS17336.1
    UniProtKB/Swiss-Prot
    O35710, Q9QZG9
    UniProtKB/TrEMBL
    B2RTJ8
    Related
    ENSMUSP00000023849.9, ENSMUST00000023849.15
    Conserved Domains (1) summary
    cd09096
    Location:142421
    Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51131868..51159075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500956.1XP_006501019.1  nocturnin isoform X1

    Conserved Domains (1) summary
    cd09096
    Location:85364
    Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains