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MSI2 musashi RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 124540, updated on 24-Nov-2020

Summary

Official Symbol
MSI2provided by HGNC
Official Full Name
musashi RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:18585
See related
Ensembl:ENSG00000153944 MIM:607897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSI2H
Summary
This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in adrenal (RPKM 11.7), ovary (RPKM 7.0) and 24 other tissues See more
Orthologs

Genomic context

See MSI2 in Genome Data Viewer
Location:
17q22
Exon count:
20
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (57255851..57684689)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55333931..55762050)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 pseudogene 1 Neighboring gene A-kinase anchoring protein 1 Neighboring gene uncharacterized LOC101927510 Neighboring gene uncharacterized LOC101927557 Neighboring gene uncharacterized LOC107984993 Neighboring gene uncharacterized LOC101927539 Neighboring gene RNA, 7SL, cytoplasmic 449, pseudogene Neighboring gene RNA, U7 small nuclear 134 pseudogene Neighboring gene coiled-coil domain containing 182

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of coronary artery calcification among African Americans, a meta-analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3245, FLJ36569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
stem cell development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polysome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein Musashi homolog 2
Names
musashi homolog 2
musashi-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322250.2NP_001309179.1  RNA-binding protein Musashi homolog 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC005325, AI416968, AK295060
    Consensus CDS
    CCDS82168.1
    UniProtKB/TrEMBL
    B4DHE8
    Related
    ENSP00000414671.2, ENST00000416426.6
    Conserved Domains (3) summary
    cd12323
    Location:89162
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:175
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:13321
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. NM_001322251.2NP_001309180.1  RNA-binding protein Musashi homolog 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC007431, AC015883, AC091181
    Conserved Domains (2) summary
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  3. NM_138962.4NP_620412.1  RNA-binding protein Musashi homolog 2 isoform a

    See identical proteins and their annotated locations for NP_620412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AC005325, AC015883, AC091181, AI416968, BC001526
    Consensus CDS
    CCDS11596.1
    UniProtKB/Swiss-Prot
    Q96DH6
    Related
    ENSP00000284073.2, ENST00000284073.7
    Conserved Domains (3) summary
    TIGR01628
    Location:35325
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  4. NM_170721.2NP_733839.1  RNA-binding protein Musashi homolog 2 isoform b

    See identical proteins and their annotated locations for NP_733839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTR and coding region, compared to variant 1. The resulting isoform (b) contains distinct N- and C-termini compared to isoform a.
    Source sequence(s)
    AC007431, AC015883, AC091181
    Consensus CDS
    CCDS11597.1
    UniProtKB/Swiss-Prot
    Q96DH6
    Related
    ENSP00000313616.3, ENST00000322684.7
    Conserved Domains (2) summary
    cd12323
    Location:107180
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:1893
    RRM1_MSI2; RNA recognition motif 1 in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    57255851..57684689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257014.3XP_005257071.1  RNA-binding protein Musashi homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005257071.1

    Related
    ENSP00000501595.1, ENST00000675656.1
    Conserved Domains (3) summary
    TIGR01628
    Location:35343
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  2. XM_005257015.3XP_005257072.1  RNA-binding protein Musashi homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_005257072.1

    Conserved Domains (3) summary
    TIGR01628
    Location:35331
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  3. XM_017024148.1XP_016879637.1  RNA-binding protein Musashi homolog 2 isoform X4

  4. XM_017024147.2XP_016879636.1  RNA-binding protein Musashi homolog 2 isoform X3

    Conserved Domains (3) summary
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl17169
    Location:22153
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:35312
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  5. XM_011524286.2XP_011522588.1  RNA-binding protein Musashi homolog 2 isoform X6

    See identical proteins and their annotated locations for XP_011522588.1

    Conserved Domains (2) summary
    cd12323
    Location:780
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:20239
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  6. XM_017024149.2XP_016879638.1  RNA-binding protein Musashi homolog 2 isoform X5

  7. XM_011524287.3XP_011522589.1  RNA-binding protein Musashi homolog 2 isoform X7

    Conserved Domains (2) summary
    COG0724
    Location:20106
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:1968
    RRM_SF; RNA recognition motif (RRM) superfamily
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