Ccnk cyclin K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnkprovided by MGI
Official Full Name: cyclin Kprovided by MGI
Primary source: MGI:MGI:1276106
See related: Ensembl:ENSMUSG00000021258 AllianceGenome:MGI:1276106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CPR4; CycK
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 101.3), limb E14.5 (RPKM 9.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 59.23 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (108145598..108170250)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (108179308..108203359)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.
Title: A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis.
Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.
Title: Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ccnk gene: The Ccnk gene is conserved in human, chimpanzee, Rhesus monkey, cow, rat, chicken, zebrafish, S.pombe, and frog.
Orthologs from Annotation Pipeline: 491 organisms have orthologs with human gene Ccnk
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cyclin K-CDK12 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin K-CDK13 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: cyclin-K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009832.2 → NP_033962.2 cyclin-K

See identical proteins and their annotated locations for NP_033962.2

Status: VALIDATED

Source sequence(s)

AK146711, CA984404

Consensus CDS

CCDS49165.1

UniProtKB/TrEMBL

Q3U3M5

Related

ENSMUSP00000152784.2, ENSMUST00000221167.2

Conserved Domains (1) summary

COG5333
Location:25 → 217

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

108145598..108170250

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515443.5 → XP_006515506.1 cyclin-K isoform X1

See identical proteins and their annotated locations for XP_006515506.1

UniProtKB/TrEMBL

Q3U3M5

Conserved Domains (1) summary

COG5333
Location:25 → 217

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
XM_006515444.5 → XP_006515507.1 cyclin-K isoform X1

See identical proteins and their annotated locations for XP_006515507.1

UniProtKB/TrEMBL

Q3U3M5

Conserved Domains (1) summary

COG5333
Location:25 → 217

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
XM_006515445.3 → XP_006515508.1 cyclin-K isoform X1

See identical proteins and their annotated locations for XP_006515508.1

UniProtKB/TrEMBL

Q3U3M5

Conserved Domains (1) summary

COG5333
Location:25 → 217

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]