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Ccnk cyclin K [ Mus musculus (house mouse) ]

Gene ID: 12454, updated on 12-Aug-2019

Summary

Official Symbol
Ccnkprovided by MGI
Official Full Name
cyclin Kprovided by MGI
Primary source
MGI:MGI:1276106
See related
Ensembl:ENSMUSG00000021258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPR4; CycK; AW123198; AW413594
Expression
Biased expression in testis adult (RPKM 101.3), limb E14.5 (RPKM 9.5) and 7 other tissues See more
Orthologs

Genomic context

See Ccnk in Genome Data Viewer
Location:
12 F1; 12 59.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108179308..108203359)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109417948..109441569)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33341 Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene SET domain containing 3 Neighboring gene coiled-coil domain containing 85C Neighboring gene hedgehog interacting protein-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cyclin K-CDK12 complex ISO
Inferred from Sequence Orthology
more info
 
cyclin K-CDK13 complex ISO
Inferred from Sequence Orthology
more info
 
cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009832.2NP_033962.2  cyclin-K

    See identical proteins and their annotated locations for NP_033962.2

    Status: VALIDATED

    Source sequence(s)
    AK146711, CA984404
    Consensus CDS
    CCDS49165.1
    UniProtKB/TrEMBL
    Q3U3M5
    Related
    ENSMUSP00000152784.1, ENSMUST00000221167.1
    Conserved Domains (1) summary
    cd00043
    Location:50148
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p6 C57BL/6J

    Range
    108179308..108203359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515444.4XP_006515507.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_006515507.1

    UniProtKB/TrEMBL
    Q3U3M5
    Conserved Domains (1) summary
    cd00043
    Location:50148
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. XM_006515443.4XP_006515506.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_006515506.1

    UniProtKB/TrEMBL
    Q3U3M5
    Conserved Domains (1) summary
    cd00043
    Location:50148
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  3. XM_006515445.2XP_006515508.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_006515508.1

    UniProtKB/TrEMBL
    Q3U3M5
    Related
    ENSMUSP00000098616.4, ENSMUST00000101055.4
    Conserved Domains (1) summary
    cd00043
    Location:50148
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
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