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ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 [ Homo sapiens (human) ]

Gene ID: 124401, updated on 23-Nov-2021

Summary

Official Symbol
ANKS3provided by HGNC
Official Full Name
ankyrin repeat and sterile alpha motif domain containing 3provided by HGNC
Primary source
HGNC:HGNC:29422
See related
Ensembl:ENSG00000168096 MIM:617310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 3.4), kidney (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See ANKS3 in Genome Data Viewer
Location:
16p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4696510..4734347, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4746512..4784272, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mahogunin ring finger 1 Neighboring gene microRNA 6769a Neighboring gene nudix hydrolase 16 like 1 Neighboring gene Sharpr-MPRA regulatory region 8628 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene zinc finger protein 500 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32345, FLJ32767, KIAA1977

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ankyrin repeat and SAM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242929.2NP_001229858.1  ankyrin repeat and SAM domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001229858.1

    Status: VALIDATED

    Source sequence(s)
    AC020663, AC023830, AI560632, AK123496, BX333650, DR004376
    Consensus CDS
    CCDS73820.1
    UniProtKB/Swiss-Prot
    Q6ZW76
    UniProtKB/TrEMBL
    F6WF08
    Related
    ENSP00000388270.3, ENST00000450067.6
    Conserved Domains (5) summary
    cd09519
    Location:317380
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:315375
    SAM; Sterile alpha motif
    cd00204
    Location:39114
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:62113
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:6192
    ANK; ANK repeat [structural motif]
  2. NM_001308089.2NP_001295018.1  ankyrin repeat and SAM domain-containing protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001295018.1

    Status: VALIDATED

    Source sequence(s)
    AB075857, AC020663, AC023830, BC032314, BC050387
    Consensus CDS
    CCDS76813.1
    UniProtKB/Swiss-Prot
    Q6ZW76
    UniProtKB/TrEMBL
    D3DUE4, Q86W77
    Conserved Domains (3) summary
    cd09519
    Location:295358
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:636
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:170
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001324129.2NP_001311058.1  ankyrin repeat and SAM domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC020663, AC023830
    Conserved Domains (3) summary
    cd09519
    Location:251314
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    cd00204
    Location:148
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:126
    ANK; ANK repeat [structural motif]
  4. NM_001324130.2NP_001311059.1  ankyrin repeat and SAM domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC020663, AC023830
    Conserved Domains (1) summary
    cd09519
    Location:134197
    SAM_ANKS3; SAM domain of ANKS3 subfamily
  5. NM_133450.4NP_597707.1  ankyrin repeat and SAM domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_597707.1

    Status: VALIDATED

    Source sequence(s)
    AC020663, AI560632, AK123496
    Consensus CDS
    CCDS10520.1
    UniProtKB/Swiss-Prot
    Q6ZW76
    Related
    ENSP00000304586.4, ENST00000304283.9
    Conserved Domains (4) summary
    cd09519
    Location:424487
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    cd00204
    Location:63189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:6999
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:173221
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_040252.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC020663, AI560632, AK123496, BM545219, DR004376
    Related
    ENST00000590193.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4696510..4734347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255119.3XP_005255176.1  ankyrin repeat and SAM domain-containing protein 3 isoform X5

    See identical proteins and their annotated locations for XP_005255176.1

    UniProtKB/Swiss-Prot
    Q6ZW76
    UniProtKB/TrEMBL
    D3DUE4
    Related
    ENSP00000406796.2, ENST00000446014.6
    Conserved Domains (3) summary
    cd09519
    Location:295358
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:636
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:170
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_011522373.1XP_011520675.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011520675.1

    UniProtKB/Swiss-Prot
    Q6ZW76
    Related
    ENSP00000480350.1, ENST00000614075.4
    Conserved Domains (4) summary
    cd09519
    Location:424487
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    cd00204
    Location:63189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:6999
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:173221
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_024450152.1XP_024305920.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

    Conserved Domains (4) summary
    cd09519
    Location:424487
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    cd00204
    Location:63189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:6999
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:173221
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_005255121.3XP_005255178.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

    See identical proteins and their annotated locations for XP_005255178.1

    Conserved Domains (1) summary
    cd09519
    Location:218281
    SAM_ANKS3; SAM domain of ANKS3 subfamily
  5. XM_011522374.1XP_011520676.1  ankyrin repeat and SAM domain-containing protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011520676.1

    UniProtKB/TrEMBL
    F6WF08
    Conserved Domains (5) summary
    cd09519
    Location:317380
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:315375
    SAM; Sterile alpha motif
    cd00204
    Location:39114
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:62113
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:6192
    ANK; ANK repeat [structural motif]
  6. XM_024450154.1XP_024305922.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

    Conserved Domains (1) summary
    cd09519
    Location:134197
    SAM_ANKS3; SAM domain of ANKS3 subfamily
  7. XM_011522378.1XP_011520680.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

    See identical proteins and their annotated locations for XP_011520680.1

    Conserved Domains (1) summary
    cd09519
    Location:218281
    SAM_ANKS3; SAM domain of ANKS3 subfamily
  8. XM_017022936.1XP_016878425.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

    Conserved Domains (1) summary
    cd09519
    Location:218281
    SAM_ANKS3; SAM domain of ANKS3 subfamily
  9. XM_011522372.1XP_011520674.1  ankyrin repeat and SAM domain-containing protein 3 isoform X1

    Conserved Domains (5) summary
    cd09519
    Location:436499
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:434494
    SAM; Sterile alpha motif
    cd00204
    Location:75201
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:118211
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:81111
    ANK; ANK repeat [structural motif]
  10. XM_017022935.1XP_016878424.1  ankyrin repeat and SAM domain-containing protein 3 isoform X3

  11. XM_024450153.1XP_024305921.1  ankyrin repeat and SAM domain-containing protein 3 isoform X6

    Conserved Domains (3) summary
    cd09519
    Location:251314
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    cd00204
    Location:148
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:126
    ANK; ANK repeat [structural motif]

RNA

  1. XR_002957774.1 RNA Sequence

  2. XR_001751840.1 RNA Sequence

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