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GPR139 G protein-coupled receptor 139 [ Homo sapiens (human) ]

Gene ID: 124274, updated on 1-Jun-2020

Summary

Official Symbol
GPR139provided by HGNC
Official Full Name
G protein-coupled receptor 139provided by HGNC
Primary source
HGNC:HGNC:19995
See related
Ensembl:ENSG00000180269 MIM:618448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR3; GPRg1
Summary
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GPR139 in Genome Data Viewer
Location:
16p12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (20028239..20073890, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20042981..20085100, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371116 Neighboring gene uncharacterized LOC105371117 Neighboring gene spalt like transcription factor 4 pseudogene 3 Neighboring gene uncharacterized LOC102723396

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 139
Names
G protein-coupled receptor PGR3
g(q)-coupled orphan receptor GPRg1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002911.4NP_001002911.1  probable G-protein coupled receptor 139 isoform 1

    See identical proteins and their annotated locations for NP_001002911.1

    Status: REVIEWED

    Source sequence(s)
    AC021089, AK291384, BC137237
    Consensus CDS
    CCDS32398.1
    UniProtKB/Swiss-Prot
    Q6DWJ6
    UniProtKB/TrEMBL
    A0A142CHG1
    Related
    ENSP00000458791.1, ENST00000570682.1
    Conserved Domains (1) summary
    cd15919
    Location:27296
    7tmA_GPR139; G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001318483.1NP_001305412.1  probable G-protein coupled receptor 139 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-ternimus, compared to isoform 1.
    Source sequence(s)
    AK291384, BC144547, DN693347
    UniProtKB/Swiss-Prot
    Q6DWJ6
    Conserved Domains (2) summary
    cd14964
    Location:931
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    20028239..20073890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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