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ZC3H18 zinc finger CCCH-type containing 18 [ Homo sapiens (human) ]

Gene ID: 124245, updated on 24-Nov-2020

Summary

Official Symbol
ZC3H18provided by HGNC
Official Full Name
zinc finger CCCH-type containing 18provided by HGNC
Primary source
HGNC:HGNC:25091
See related
Ensembl:ENSG00000158545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHN1
Expression
Ubiquitous expression in testis (RPKM 13.0), spleen (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See ZC3H18 in Genome Data Viewer
Location:
16q24.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (88570403..88631964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88636789..88698372)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984905 Neighboring gene ZC3H18 antisense RNA 1 (head to head) Neighboring gene interleukin 17C Neighboring gene cytochrome b-245 alpha chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22664, FLJ34530, FLJ36075

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 18
Names
conserved nuclear protein NHN1
nuclear protein NHN1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294340.2NP_001281269.1  zinc finger CCCH domain-containing protein 18 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK026317, AK300254, BC001584, CN299707, DA313229, DB007291
    Consensus CDS
    CCDS73924.1
    UniProtKB/Swiss-Prot
    Q86VM9
    UniProtKB/TrEMBL
    B4DTK7, E7ERS3
    Related
    ENSP00000416951.2, ENST00000452588.6
    Conserved Domains (1) summary
    COG5271
    Location:17187
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  2. NM_144604.4NP_653205.3  zinc finger CCCH domain-containing protein 18 isoform 2

    See identical proteins and their annotated locations for NP_653205.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK026317, BC001584, CN299704, DA313229
    Consensus CDS
    CCDS10967.1
    UniProtKB/Swiss-Prot
    Q86VM9
    Related
    ENSP00000301011.5, ENST00000301011.9
    Conserved Domains (1) summary
    smart00356
    Location:215243
    ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    88570403..88631964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522863.2XP_011521165.1  zinc finger CCCH domain-containing protein 18 isoform X1

    Conserved Domains (1) summary
    COG5271
    Location:17187
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  2. XM_017022934.2XP_016878423.1  zinc finger CCCH domain-containing protein 18 isoform X2

  3. XM_011522865.1XP_011521167.1  zinc finger CCCH domain-containing protein 18 isoform X3

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