Cbx2 chromobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbx2provided by MGI
Official Full Name: chromobox 2provided by MGI
Primary source: MGI:MGI:88289
See related: Ensembl:ENSMUSG00000025577 AllianceGenome:MGI:88289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pc; M33; MOD2
Summary: This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]
Expression: Broad expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.33 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118913845..118922101)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (119023019..119031275)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CBX2 in DSD: The Quirky Kid on the Block.
Title: CBX2 in DSD: The Quirky Kid on the Block.
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model.
Title: Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model.
CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/beta-catenin pathway.
Title: CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway.
Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
Title: Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
This work identifies Cbx2 as a positive mediator in antiviral immunity, which provides new mechanistic insight into epigenetic modifiers in the innate immune response.
Title: Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter.
Cbx2 controls the maintenance and adipogenic differentiation of mesenchymal stromal cells in the bone marrow.
Title: Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.
The results suggest that stabilization of the testis fate requires CBX2-mediated repression of bivalent ovary-determining genes, which would otherwise block testis development.
Title: CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.
Point mutations in an internal domain of Cbx2 eliminate phase separation and eliminate the formation of puncta in cells
Title: Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2.
marker of heterochromatin formation produced by PRC2, had minimal effects on the CBX2 condensate formation
Title: Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Cbx2 gene: The Cbx2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 313 organisms have orthologs with human gene Cbx2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in development of primary sexual characteristics	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in heterochromatin	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromobox protein homolog 2

Names: M33 polycomb-like protein; chromobox homolog 2; modifier 3 protein; polycomb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007623.3 → NP_031649.2 chromobox protein homolog 2

See identical proteins and their annotated locations for NP_031649.2

Status: REVIEWED

Source sequence(s)

AK141647, BE986063, CJ176395, X62537

Consensus CDS

CCDS25708.1

UniProtKB/Swiss-Prot

P30658, Q8CIA0

UniProtKB/TrEMBL

Q3URA3

Related

ENSMUSP00000026662.8, ENSMUST00000026662.8

Conserved Domains (1) summary

pfam00385
Location:15 → 61

Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

118913845..118922101

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532104.1 → XP_006532167.1 chromobox protein homolog 2 isoform X2

Conserved Domains (2) summary

cd18647
Location:9 → 61

CD_Cbx2; chromodomain of chromobox homolog 2

pfam17218
Location:539 → 571

CBX7_C; CBX family C-terminal motif
XM_006532103.1 → XP_006532166.1 chromobox protein homolog 2 isoform X1

Conserved Domains (1) summary

pfam17218
Location:553 → 585

CBX7_C; CBX family C-terminal motif
XM_006532105.1 → XP_006532168.1 chromobox protein homolog 2 isoform X3

Conserved Domains (1) summary

pfam17218
Location:492 → 524

CBX7_C; CBX family C-terminal motif