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LTB4R leukotriene B4 receptor [ Homo sapiens (human) ]

Gene ID: 1241, updated on 17-Sep-2024

Summary

Official Symbol
LTB4Rprovided by HGNC
Official Full Name
leukotriene B4 receptorprovided by HGNC
Primary source
HGNC:HGNC:6713
See related
Ensembl:ENSG00000213903 MIM:601531; AllianceGenome:HGNC:6713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1
Summary
Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 33.9), esophagus (RPKM 9.6) and 10 other tissues See more
Orthologs
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Genomic context

See LTB4R in Genome Data Viewer
Location:
14q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24311502..24318036)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18509845..18516371)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24780708..24787242)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NOP9 nucleolar protein Neighboring gene dehydrogenase/reductase 1 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5636 Neighboring gene cell death inducing DFFA like effector b Neighboring gene leukotriene B4 receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24785286-24785786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24790818-24791777 Neighboring gene adenylate cyclase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5639 Neighboring gene Sharpr-MPRA regulatory region 10023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8216 Neighboring gene receptor interacting serine/threonine kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables leukotriene B4 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables leukotriene receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leukotriene B4 receptor 1
Names
G protein-coupled receptor 16
LTB4-R 1
LTB4-R1
P2Y purinoceptor 7
chemoattractant receptor-like 1
chemokine receptor-like 1
purinergic receptor P2Y, G-protein coupled, 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143919.3NP_001137391.1  leukotriene B4 receptor 1

    See identical proteins and their annotated locations for NP_001137391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL096870, BQ182452, D89079
    Consensus CDS
    CCDS9626.1
    UniProtKB/Swiss-Prot
    Q13305, Q15722, Q53XV5, Q92641, Q9BSU5
    Related
    ENSP00000307445.3, ENST00000345363.8
    Conserved Domains (1) summary
    pfam00001
    Location:35285
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_181657.3NP_858043.1  leukotriene B4 receptor 1

    See identical proteins and their annotated locations for NP_858043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL096870, BQ182452
    Consensus CDS
    CCDS9626.1
    UniProtKB/Swiss-Prot
    Q13305, Q15722, Q53XV5, Q92641, Q9BSU5
    Related
    ENSP00000380008.4, ENST00000396789.4
    Conserved Domains (1) summary
    pfam00001
    Location:35285
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24311502..24318036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    612480..619014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18509845..18516371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)