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NOXO1 NADPH oxidase organizer 1 [ Homo sapiens (human) ]

Gene ID: 124056, updated on 21-Dec-2019

Summary

Official Symbol
NOXO1provided by HGNC
Official Full Name
NADPH oxidase organizer 1provided by HGNC
Primary source
HGNC:HGNC:19404
See related
Ensembl:ENSG00000196408 MIM:611256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5
Summary
This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Expression
Broad expression in colon (RPKM 2.7), appendix (RPKM 0.9) and 14 other tissues See more
Orthologs

Genomic context

See NOXO1 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1978917..1984027, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2028918..2031704, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 78 Neighboring gene small nucleolar RNA host gene 9 Neighboring gene ring finger protein 151 Neighboring gene transducin beta like 3 Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene synaptogyrin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20258

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide-generating NADPH oxidase activator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of hydrogen peroxide metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of respiratory burst TAS
Traceable Author Statement
more info
PubMed 
superoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
NADPH oxidase organizer 1
Names
NADPH oxidase regulatory protein
Nox organizer 1
SH3 and PX domain-containing protein 5
nox-organizing protein 1
regulatory protein P41NOX

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267721.2NP_001254650.1  NADPH oxidase organizer 1 isoform d

    See identical proteins and their annotated locations for NP_001254650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) uses an alternate splice site compared to variant a, but maintains the same reading frame. The encoded isoform (d) is longer than isoform a.
    Source sequence(s)
    AK292197, AY191359
    Consensus CDS
    CCDS58406.1
    UniProtKB/Swiss-Prot
    Q8NFA2
    UniProtKB/TrEMBL
    A8K832
    Related
    ENSP00000456800.1, ENST00000566005.5
    Conserved Domains (3) summary
    cd12023
    Location:166221
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:240292
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3126
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. NM_144603.4NP_653204.1  NADPH oxidase organizer 1 isoform a

    See identical proteins and their annotated locations for NP_653204.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the shortest transcript and encodes the shortest isoform (a).
    Source sequence(s)
    BC015917, DB009385
    Consensus CDS
    CCDS10454.1
    UniProtKB/Swiss-Prot
    Q8NFA2
    Related
    ENSP00000346195.4, ENST00000354249.8
    Conserved Domains (3) summary
    cd12023
    Location:161216
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:235287
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3121
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  3. NM_172167.3NP_751907.1  NADPH oxidase organizer 1 isoform b

    See identical proteins and their annotated locations for NP_751907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant a. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AF532984, AK292197
    Consensus CDS
    CCDS10455.1
    UniProtKB/Swiss-Prot
    Q8NFA2
    UniProtKB/TrEMBL
    A8K832
    Related
    ENSP00000348435.4, ENST00000356120.8
    Conserved Domains (3) summary
    cd12023
    Location:162217
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:236288
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3122
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  4. NM_172168.3NP_751908.1  NADPH oxidase organizer 1 isoform c

    See identical proteins and their annotated locations for NP_751908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) uses two alternate splice sites compared to variant a, but maintains the same reading frame. The encoded isoform (c) is longer than isoform a.
    Source sequence(s)
    AF532985, AK292197
    Consensus CDS
    CCDS42101.1
    UniProtKB/Swiss-Prot
    Q8NFA2
    UniProtKB/TrEMBL
    A8K832
    Related
    ENSP00000380450.4, ENST00000397280.8
    Conserved Domains (3) summary
    cd12023
    Location:167222
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:241293
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3127
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1978917..1984027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022927.2XP_016878416.1  NADPH oxidase organizer 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFA2
    Conserved Domains (3) summary
    cd12023
    Location:167222
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:241293
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3127
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_005255099.5XP_005255156.1  NADPH oxidase organizer 1 isoform X1

    See identical proteins and their annotated locations for XP_005255156.1

    UniProtKB/Swiss-Prot
    Q8NFA2
    Conserved Domains (3) summary
    cd12023
    Location:167222
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:241293
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3127
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  3. XM_017022928.1XP_016878417.1  NADPH oxidase organizer 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFA2
    Conserved Domains (3) summary
    cd12023
    Location:167222
    SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
    cd12024
    Location:241293
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3127
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
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