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Cbln1 cerebellin 1 precursor protein [ Mus musculus (house mouse) ]

Gene ID: 12404, updated on 31-Jan-2023

Summary

Official Symbol
Cbln1provided by MGI
Official Full Name
cerebellin 1 precursor proteinprovided by MGI
Primary source
MGI:MGI:88281
See related
Ensembl:ENSMUSG00000031654 AllianceGenome:MGI:88281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables identical protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of synapse assembly. Acts upstream of or within positive regulation of synapse assembly and protein secretion. Located in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and synaptic cleft. Is expressed in several structures, including central nervous system; limb; oral region epithelium; reproductive system; and sensory organ. Orthologous to human CBLN1 (cerebellin 1 precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 226.7), whole brain E14.5 (RPKM 20.2) and 2 other tissues See more
Orthologs
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Genomic context

See Cbln1 in Genome Data Viewer
Location:
8 C3; 8 42.16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88195481..88199220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (87468853..87472592, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930535O05 gene Neighboring gene predicted gene, 19872 Neighboring gene predicted gene 2694 Neighboring gene RIKEN cDNA 4933402J07 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cerebellar granule cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in maintenance of synapse structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maintenance of synapse structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inhibitory synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of synapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic cleft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cerebellin-1
Names
brain protein D3
precerebellin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019626.3NP_062600.2  cerebellin-1 precursor

    See identical proteins and their annotated locations for NP_062600.2

    Status: VALIDATED

    Source sequence(s)
    AI894057, AK158885
    Consensus CDS
    CCDS22506.1
    UniProtKB/Swiss-Prot
    Q9QVT5, Q9R171
    UniProtKB/TrEMBL
    A0A6P5QAW5, A0A8C6H843, A2RSI1, Q7TNF5
    Related
    ENSMUSP00000034076.9, ENSMUST00000034076.16
    Conserved Domains (1) summary
    smart00110
    Location:55193
    C1Q; Complement component C1q domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    88195481..88199220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)