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CMTM3 CKLF like MARVEL transmembrane domain containing 3 [ Homo sapiens (human) ]

Gene ID: 123920, updated on 13-Feb-2019

Summary

Official Symbol
CMTM3provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 3provided by HGNC
Primary source
HGNC:HGNC:19174
See related
Ensembl:ENSG00000140931 MIM:607886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNAS2; CKLFSF3
Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 24.7), placenta (RPKM 16.7) and 24 other tissues See more
Orthologs

Genomic context

See CMTM3 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (66603996..66613892)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66637935..66647795)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene CKLF like MARVEL transmembrane domain containing 4 Neighboring gene putative uncharacterized protein encoded by LINC00269 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2 Neighboring gene uncharacterized LOC106699570

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31762, MGC51956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 3
Names
chemokine-like factor superfamily member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363918.1NP_001350847.1  CKLF-like MARVEL transmembrane domain-containing protein 3

    Status: REVIEWED

    Source sequence(s)
    AC018557
    Consensus CDS
    CCDS10815.1
    Conserved Domains (1) summary
    pfam01284
    Location:36149
    MARVEL; Membrane-associating domain
  2. NM_001363923.1NP_001350852.1  CKLF-like MARVEL transmembrane domain-containing protein 3

    Status: REVIEWED

    Source sequence(s)
    AC018557, AF479813, AK056324
    Conserved Domains (1) summary
    pfam01284
    Location:36149
    MARVEL; Membrane-associating domain
  3. NM_144601.4NP_653202.1  CKLF-like MARVEL transmembrane domain-containing protein 3

    See identical proteins and their annotated locations for NP_653202.1

    Status: REVIEWED

    Source sequence(s)
    AC018557, AF479813
    Consensus CDS
    CCDS10815.1
    UniProtKB/Swiss-Prot
    Q96MX0
    UniProtKB/TrEMBL
    A0A024R6Y8
    Related
    ENSP00000354579.4, ENST00000361909.8
    Conserved Domains (1) summary
    pfam01284
    Location:36149
    MARVEL; Membrane-associating domain
  4. NM_181553.4NP_853531.1  CKLF-like MARVEL transmembrane domain-containing protein 3

    See identical proteins and their annotated locations for NP_853531.1

    Status: REVIEWED

    Source sequence(s)
    AF479813, BC047701
    Consensus CDS
    CCDS10815.1
    UniProtKB/Swiss-Prot
    Q96MX0
    UniProtKB/TrEMBL
    A0A024R6Y8
    Related
    ENSP00000455851.1, ENST00000567572.5
    Conserved Domains (1) summary
    pfam01284
    Location:36149
    MARVEL; Membrane-associating domain

RNA

  1. NR_037619.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018557, AF479813, CT001840
    Related
    ENST00000566756.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    66603996..66613892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721131.2XP_006721194.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q96MX0
    UniProtKB/TrEMBL
    A0A024R6Y8
    Related
    ENSP00000400482.2, ENST00000424011.6
    Conserved Domains (1) summary
    pfam01284
    Location:36149
    MARVEL; Membrane-associating domain
  2. XM_011522861.1XP_011521163.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    H3BUD5
    Related
    ENSP00000457589.1, ENST00000564060.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048251.1: Suppressed sequence

    Description
    NM_001048251.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_181554.1: Suppressed sequence

    Description
    NM_181554.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_181555.1: Suppressed sequence

    Description
    NM_181555.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript variant.
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